Synthesis, biological evaluation and in silico and in vitro mode-of-action analysis of novel dihydropyrimidones targeting PPAR-y

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Synthesis, biological evaluation and in silico and in vitro mode-of-action analysis of novel dihydropyrimidones targeting PPAR-y

Hepatocellular carcinoma, a fatal liver cancer, affects 600 000 people annually and ranks third in cancer-related lethality. In this work we report the synthesis and related biological activity of novel dihydropyrimidones. Among the tested compounds, 5-acetyl-4-(1H-indol-3-yl)-6-methyl-3,4-dihydropy...

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Bibliographic Details
Main Authors:	Bharathkumar, H., Paricharak, S., Dinesh, K., Siveen, S., Fuchs, J., Rangappa, S., Mohan, C., Mohandas, N., Kumar, Alan Prem, Sethi, G., Bender, A., Basappa, Rangappa, K.
Format:	Journal Article
Published:	Royal Society of Chemistry 2014
Online Access:	http://hdl.handle.net/20.500.11937/28077

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