Pharmacokinetics of dihydroartemisinin in a murine malaria model

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Pharmacokinetics of dihydroartemisinin in a murine malaria model

Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 L/hr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokine...

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Bibliographic Details
Main Authors:	Batty, Kevin, Gibbons, Peter, Davis, Timothy, Ilett, K.
Format:	Journal Article
Published:	The American Society of Tropical Medicine and Hygiene 2008
Online Access:	http://hdl.handle.net/20.500.11937/27968

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