Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system
This study was undertaken to compare the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine for the prevention of mastitis using the mouse as a model system. Mice immunized with formalin-killed whole cell vaccine of S. aureus residing in a biofilm when del...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Taylor and Francis Ltd.
2015
|
| Online Access: | http://hdl.handle.net/20.500.11937/27859 |
| _version_ | 1848752380422651904 |
|---|---|
| author | Gogoi Tiwari, Jully Williams, Vincent Waryah, C. Eto, K. Tau, M. Costantino, Paul Tiwari, H. Mukkur, Trilochan |
| author_facet | Gogoi Tiwari, Jully Williams, Vincent Waryah, C. Eto, K. Tau, M. Costantino, Paul Tiwari, H. Mukkur, Trilochan |
| author_sort | Gogoi Tiwari, Jully |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This study was undertaken to compare the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine for the prevention of mastitis using the mouse as a model system. Mice immunized with formalin-killed whole cell vaccine of S. aureus residing in a biofilm when delivered via an intramammary route produced a cell mediated immune response. Mice immunized with this biofilm vaccine showed significant reductions in colonization by S. aureus in mammary glands, severity of clinical symptoms and tissue damage in mammary glands in comparison with the mice immunized with formalin-killed whole cells of planktonic S. aureus. The planktonic vaccine administered by a subcutaneous route produced a significantly higher humoral immune response (IgG1 and IgG) than the biofilm vaccine. However, considering the host response, tissue damage, the clinical severity and colonization of S. aureus in mammary glands, the biofilm vaccine performed better in immunogenicity and protective potential when administered by the intramammary route. |
| first_indexed | 2025-11-14T08:07:42Z |
| format | Journal Article |
| id | curtin-20.500.11937-27859 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:07:42Z |
| publishDate | 2015 |
| publisher | Taylor and Francis Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-278592017-09-13T15:46:59Z Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system Gogoi Tiwari, Jully Williams, Vincent Waryah, C. Eto, K. Tau, M. Costantino, Paul Tiwari, H. Mukkur, Trilochan This study was undertaken to compare the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine for the prevention of mastitis using the mouse as a model system. Mice immunized with formalin-killed whole cell vaccine of S. aureus residing in a biofilm when delivered via an intramammary route produced a cell mediated immune response. Mice immunized with this biofilm vaccine showed significant reductions in colonization by S. aureus in mammary glands, severity of clinical symptoms and tissue damage in mammary glands in comparison with the mice immunized with formalin-killed whole cells of planktonic S. aureus. The planktonic vaccine administered by a subcutaneous route produced a significantly higher humoral immune response (IgG1 and IgG) than the biofilm vaccine. However, considering the host response, tissue damage, the clinical severity and colonization of S. aureus in mammary glands, the biofilm vaccine performed better in immunogenicity and protective potential when administered by the intramammary route. 2015 Journal Article http://hdl.handle.net/20.500.11937/27859 10.1080/08927014.2015.1074681 Taylor and Francis Ltd. restricted |
| spellingShingle | Gogoi Tiwari, Jully Williams, Vincent Waryah, C. Eto, K. Tau, M. Costantino, Paul Tiwari, H. Mukkur, Trilochan Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system |
| title | Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system |
| title_full | Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system |
| title_fullStr | Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system |
| title_full_unstemmed | Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system |
| title_short | Comparative studies of the immunogenicity and protective potential of biofilm vs planktonic Staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system |
| title_sort | comparative studies of the immunogenicity and protective potential of biofilm vs planktonic staphylococcus aureus vaccine against bovine mastitis using non-invasive mouse mastitis as a model system |
| url | http://hdl.handle.net/20.500.11937/27859 |