Pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions
In this work, the modulation of the diffusion potential formed at the microfluidic aqueous–aqueous boundary by a pharmaceutical substance is presented. Co-flowing aqueous streams in a microchannel were used to form the stable boundary between the streams. Measurement of the open circuit potential be...
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| Format: | Journal Article |
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Wiley-VCH Verlag
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/2782 |
| _version_ | 1848744046771568640 |
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| author | Collins, C. Strutwolf, J. Arrigan, Damien |
| author_facet | Collins, C. Strutwolf, J. Arrigan, Damien |
| author_sort | Collins, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In this work, the modulation of the diffusion potential formed at the microfluidic aqueous–aqueous boundary by a pharmaceutical substance is presented. Co-flowing aqueous streams in a microchannel were used to form the stable boundary between the streams. Measurement of the open circuit potential between two silver/silver chloride electrodes enabled the diffusion potential at the boundary to be determined, which is concentration dependent. Experimental results for protonated propranolol as well as tetrapropylammonium are presented. This concept may be useful as a strategy for the detection of drug substances. |
| first_indexed | 2025-11-14T05:55:14Z |
| format | Journal Article |
| id | curtin-20.500.11937-2782 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T05:55:14Z |
| publishDate | 2011 |
| publisher | Wiley-VCH Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-27822017-09-13T16:02:17Z Pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions Collins, C. Strutwolf, J. Arrigan, Damien Microfluidic Propranolol Liquid junction Potentiometry Diffusion potential In this work, the modulation of the diffusion potential formed at the microfluidic aqueous–aqueous boundary by a pharmaceutical substance is presented. Co-flowing aqueous streams in a microchannel were used to form the stable boundary between the streams. Measurement of the open circuit potential between two silver/silver chloride electrodes enabled the diffusion potential at the boundary to be determined, which is concentration dependent. Experimental results for protonated propranolol as well as tetrapropylammonium are presented. This concept may be useful as a strategy for the detection of drug substances. 2011 Journal Article http://hdl.handle.net/20.500.11937/2782 10.1002/elps.201000299 Wiley-VCH Verlag restricted |
| spellingShingle | Microfluidic Propranolol Liquid junction Potentiometry Diffusion potential Collins, C. Strutwolf, J. Arrigan, Damien Pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions |
| title | Pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions |
| title_full | Pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions |
| title_fullStr | Pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions |
| title_full_unstemmed | Pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions |
| title_short | Pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions |
| title_sort | pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions |
| topic | Microfluidic Propranolol Liquid junction Potentiometry Diffusion potential |
| url | http://hdl.handle.net/20.500.11937/2782 |