Plasma iron and iron delivery to the tissues
Iron is a transition element which has two biologically important oxidation states, +2 and +3. It is an essential trace element and, as such, takes part in a large number of varied biological processes, many of which utilize the interconversion of ferrous and ferric iron. Ferrous iron is relatively...
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| Format: | Book Chapter |
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Humana Press
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/27709 |
| _version_ | 1848752338443960320 |
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| author | Graham, Ross Chua, A. Trinder, D. |
| author2 | Gregory J Anderson |
| author_facet | Gregory J Anderson Graham, Ross Chua, A. Trinder, D. |
| author_sort | Graham, Ross |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Iron is a transition element which has two biologically important oxidation states, +2 and +3. It is an essential trace element and, as such, takes part in a large number of varied biological processes, many of which utilize the interconversion of ferrous and ferric iron. Ferrous iron is relatively soluble but is readily oxidized to the ferric form which is sparingly soluble at physiological pH and will precipitate if not solubilized. It is also possible for the electron released from the oxidation reaction to participate in the formation of reactive oxygen species which can cause oxidative damage if present in high enough concentrations. Consequently, many elegant processes have evolved which render iron both soluble and non-toxic, allowing organisms to accumulate iron in forms which are both safe and functional.This chapter will provide an overview of the normal processes of iron transport in mammals, including a summary of the transport molecules and their mechanisms of iron capture and release. We will also outline the mechanisms of iron acquisition by tissues and the regulation of these processes. |
| first_indexed | 2025-11-14T08:07:02Z |
| format | Book Chapter |
| id | curtin-20.500.11937-27709 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:07:02Z |
| publishDate | 2012 |
| publisher | Humana Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-277092023-02-07T08:01:18Z Plasma iron and iron delivery to the tissues Graham, Ross Chua, A. Trinder, D. Gregory J Anderson Gordon D McLaren transferrin receptor receptor-mediated endocytosis non-transferrin-bound iron iron uptake transferrin plasma iron liver HFE metal binding transferrin-bound iron Iron is a transition element which has two biologically important oxidation states, +2 and +3. It is an essential trace element and, as such, takes part in a large number of varied biological processes, many of which utilize the interconversion of ferrous and ferric iron. Ferrous iron is relatively soluble but is readily oxidized to the ferric form which is sparingly soluble at physiological pH and will precipitate if not solubilized. It is also possible for the electron released from the oxidation reaction to participate in the formation of reactive oxygen species which can cause oxidative damage if present in high enough concentrations. Consequently, many elegant processes have evolved which render iron both soluble and non-toxic, allowing organisms to accumulate iron in forms which are both safe and functional.This chapter will provide an overview of the normal processes of iron transport in mammals, including a summary of the transport molecules and their mechanisms of iron capture and release. We will also outline the mechanisms of iron acquisition by tissues and the regulation of these processes. 2012 Book Chapter http://hdl.handle.net/20.500.11937/27709 Humana Press restricted |
| spellingShingle | transferrin receptor receptor-mediated endocytosis non-transferrin-bound iron iron uptake transferrin plasma iron liver HFE metal binding transferrin-bound iron Graham, Ross Chua, A. Trinder, D. Plasma iron and iron delivery to the tissues |
| title | Plasma iron and iron delivery to the tissues |
| title_full | Plasma iron and iron delivery to the tissues |
| title_fullStr | Plasma iron and iron delivery to the tissues |
| title_full_unstemmed | Plasma iron and iron delivery to the tissues |
| title_short | Plasma iron and iron delivery to the tissues |
| title_sort | plasma iron and iron delivery to the tissues |
| topic | transferrin receptor receptor-mediated endocytosis non-transferrin-bound iron iron uptake transferrin plasma iron liver HFE metal binding transferrin-bound iron |
| url | http://hdl.handle.net/20.500.11937/27709 |