Crystallisation of lactose monohydrate from DMSO solutions: Influence of lactose
In this study, the dimethyl sulfoxide (DMSO)-lactose system has been used to study the effect of lactose on the morphology of lactose monohydrate crystals. DMSO was used as the solvent as it greatly reduces the rate of mutarotation of lactose to lactose. It is shown that as the content of the soluti...
| Main Authors: | , , , |
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| Format: | Journal Article |
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Elsevier Science
1999
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| Online Access: | http://hdl.handle.net/20.500.11937/27512 |
| _version_ | 1848752284262989824 |
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| author | Dincer, Tuna Parkinson, Gordon Rohl, Andrew Ogden, Mark |
| author_facet | Dincer, Tuna Parkinson, Gordon Rohl, Andrew Ogden, Mark |
| author_sort | Dincer, Tuna |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In this study, the dimethyl sulfoxide (DMSO)-lactose system has been used to study the effect of lactose on the morphology of lactose monohydrate crystals. DMSO was used as the solvent as it greatly reduces the rate of mutarotation of lactose to lactose. It is shown that as the content of the solution increases, the crystal shape starts increasing in the a and b directions, whereas the major growth occurs in the c direction at low levels of lactose.The morphology of the lactose monohydrate crystal calculated by molecular modelling isin good agreement with that of the crystals grown in the presence of low lactose concentrations. Atomic force microscopy has revealed growth spirals and unit cell high steps on the (020) face of crystals grown in the presence of low anomer concentration. |
| first_indexed | 2025-11-14T08:06:10Z |
| format | Journal Article |
| id | curtin-20.500.11937-27512 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:06:10Z |
| publishDate | 1999 |
| publisher | Elsevier Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-275122018-10-03T05:38:20Z Crystallisation of lactose monohydrate from DMSO solutions: Influence of lactose Dincer, Tuna Parkinson, Gordon Rohl, Andrew Ogden, Mark lactose - crystal growth - atomic force microscopy In this study, the dimethyl sulfoxide (DMSO)-lactose system has been used to study the effect of lactose on the morphology of lactose monohydrate crystals. DMSO was used as the solvent as it greatly reduces the rate of mutarotation of lactose to lactose. It is shown that as the content of the solution increases, the crystal shape starts increasing in the a and b directions, whereas the major growth occurs in the c direction at low levels of lactose.The morphology of the lactose monohydrate crystal calculated by molecular modelling isin good agreement with that of the crystals grown in the presence of low lactose concentrations. Atomic force microscopy has revealed growth spirals and unit cell high steps on the (020) face of crystals grown in the presence of low anomer concentration. 1999 Journal Article http://hdl.handle.net/20.500.11937/27512 10.1016/S0022-0248(99)00238-9 Elsevier Science fulltext |
| spellingShingle | lactose - crystal growth - atomic force microscopy Dincer, Tuna Parkinson, Gordon Rohl, Andrew Ogden, Mark Crystallisation of lactose monohydrate from DMSO solutions: Influence of lactose |
| title | Crystallisation of lactose monohydrate from DMSO solutions: Influence of lactose |
| title_full | Crystallisation of lactose monohydrate from DMSO solutions: Influence of lactose |
| title_fullStr | Crystallisation of lactose monohydrate from DMSO solutions: Influence of lactose |
| title_full_unstemmed | Crystallisation of lactose monohydrate from DMSO solutions: Influence of lactose |
| title_short | Crystallisation of lactose monohydrate from DMSO solutions: Influence of lactose |
| title_sort | crystallisation of lactose monohydrate from dmso solutions: influence of lactose |
| topic | lactose - crystal growth - atomic force microscopy |
| url | http://hdl.handle.net/20.500.11937/27512 |