Evaluation of Electrospun Nanofibrous Structures for Drug Release Application
Biopolymers show the excellent biodegradability and efficient release sustainability for encapsulated drugs. In particular, electrospun polymer or composite fibre mats provide greater benefits owing to their competitive release properties and large specific surface area. This research work focused o...
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| Format: | Conference Paper |
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The Institution of Chemical Engineers (IChemE)
2014
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| Online Access: | http://www.icheme.org/chemeca2014/program/papers.aspx http://hdl.handle.net/20.500.11937/27438 |
| _version_ | 1848752263838826496 |
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| author | Haroosh, Hazim Jasim Mohammed Dong, Yu |
| author2 | Vishnu Pareek |
| author_facet | Vishnu Pareek Haroosh, Hazim Jasim Mohammed Dong, Yu |
| author_sort | Haroosh, Hazim Jasim Mohammed |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Biopolymers show the excellent biodegradability and efficient release sustainability for encapsulated drugs. In particular, electrospun polymer or composite fibre mats provide greater benefits owing to their competitive release properties and large specific surface area. This research work focused on electrospun nanofibres derived from poly(e-caprolactone) (PCL), poly(lactic acid) (PLA) and PCL/ magnetic nanoparticles (MPs) solutions by carrying a therapeutic compound tetracycline hydrochloride (TCH) with the potential use for medical applications. The material systems were examined to evaluate how composite constituents affected the surface morphology with the aim of drug release control. It has been found that the fibre diameter decreased considerably with the addition of TCH drug. The average fibre diameter was also reduced with additional MPs due to enhanced solution conductivity. Furthermore, Fourier transform infrared spectroscopy (FTIR) proved the successful encapsulation of TCH drug. Over short-term periods, the TCH release from PCL nanofibres was higher than PCL/ MPs and PLA nanofibres; whereas, on a long-term run, TCH release from PCL became slower owing to its high degree of crystallinity. The TCH release kinetics of PCL/ TCH nanofibres were better estimated by Zeng model when compared with PLA/TCH counterparts. |
| first_indexed | 2025-11-14T08:05:51Z |
| format | Conference Paper |
| id | curtin-20.500.11937-27438 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:05:51Z |
| publishDate | 2014 |
| publisher | The Institution of Chemical Engineers (IChemE) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-274382023-02-27T07:34:30Z Evaluation of Electrospun Nanofibrous Structures for Drug Release Application Haroosh, Hazim Jasim Mohammed Dong, Yu Vishnu Pareek Yee-Kwong Leong Mark Mullett Electrospinning Release kinetics Nanocomposites Drug release Magnetic nanoparticles Biopolymers show the excellent biodegradability and efficient release sustainability for encapsulated drugs. In particular, electrospun polymer or composite fibre mats provide greater benefits owing to their competitive release properties and large specific surface area. This research work focused on electrospun nanofibres derived from poly(e-caprolactone) (PCL), poly(lactic acid) (PLA) and PCL/ magnetic nanoparticles (MPs) solutions by carrying a therapeutic compound tetracycline hydrochloride (TCH) with the potential use for medical applications. The material systems were examined to evaluate how composite constituents affected the surface morphology with the aim of drug release control. It has been found that the fibre diameter decreased considerably with the addition of TCH drug. The average fibre diameter was also reduced with additional MPs due to enhanced solution conductivity. Furthermore, Fourier transform infrared spectroscopy (FTIR) proved the successful encapsulation of TCH drug. Over short-term periods, the TCH release from PCL nanofibres was higher than PCL/ MPs and PLA nanofibres; whereas, on a long-term run, TCH release from PCL became slower owing to its high degree of crystallinity. The TCH release kinetics of PCL/ TCH nanofibres were better estimated by Zeng model when compared with PLA/TCH counterparts. 2014 Conference Paper http://hdl.handle.net/20.500.11937/27438 http://www.icheme.org/chemeca2014/program/papers.aspx The Institution of Chemical Engineers (IChemE) fulltext |
| spellingShingle | Electrospinning Release kinetics Nanocomposites Drug release Magnetic nanoparticles Haroosh, Hazim Jasim Mohammed Dong, Yu Evaluation of Electrospun Nanofibrous Structures for Drug Release Application |
| title | Evaluation of Electrospun Nanofibrous Structures for Drug Release Application |
| title_full | Evaluation of Electrospun Nanofibrous Structures for Drug Release Application |
| title_fullStr | Evaluation of Electrospun Nanofibrous Structures for Drug Release Application |
| title_full_unstemmed | Evaluation of Electrospun Nanofibrous Structures for Drug Release Application |
| title_short | Evaluation of Electrospun Nanofibrous Structures for Drug Release Application |
| title_sort | evaluation of electrospun nanofibrous structures for drug release application |
| topic | Electrospinning Release kinetics Nanocomposites Drug release Magnetic nanoparticles |
| url | http://www.icheme.org/chemeca2014/program/papers.aspx http://hdl.handle.net/20.500.11937/27438 |