The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator

The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator

Glucocorticoids are used widely in the treatment of inflammatory diseases, but use is accompanied by a significant burden of adverse effects. It has been hypothesized that gene- and cell-specific regulation of the glucocorticoid receptor by small molecule ligands could be translated into a therapeut...

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Bibliographic Details
Main Authors: Brandish, P., Anderson, K., Baltus, G., Bai, C., Bungard, C., Bunting, P., Byford, A., Chiu, C., Cicmil, M., Corcoran, H., Euler, D., Fisher, J., Gambone, C., Hasbun-Manning, M., Kuklin, N., Landis, E., Lifsted, T., McElwee-Witmer, S., McIntosh, I., Meissner, R., Miao, J., Mitchell, H., Musselman, A., Schmidt, A., Shin, J., Szczerba, P., Thompson, C., Tribouley, C., Vogel, R., Warrier, Sudha, Hershey, J.
Format: Journal Article
Published: 2014
Online Access:http://hdl.handle.net/20.500.11937/26946

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