The impact of luteinizing hormone and testosterone on beta amyloid (Aß) accumulation: Animal and human clinical studies
This article is part of a Special Issue "SBN 2014".Hormonal changes associated with ageing have been implicated in the pathogenesis of Alzheimer's disease (AD), the most common form of dementia. Reductions in serum testosterone and increases in luteinizing hormone (LH) are established...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
Academic Press Inc.
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/26923 |
| _version_ | 1848752122663796736 |
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| author | Verdile, Giuseppe Asih, P. Barron, A. Wahjoepramono, E. Ittner, L. Martins, R. |
| author_facet | Verdile, Giuseppe Asih, P. Barron, A. Wahjoepramono, E. Ittner, L. Martins, R. |
| author_sort | Verdile, Giuseppe |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This article is part of a Special Issue "SBN 2014".Hormonal changes associated with ageing have been implicated in the pathogenesis of Alzheimer's disease (AD), the most common form of dementia. Reductions in serum testosterone and increases in luteinizing hormone (LH) are established AD risk factors for dementia in men and have important roles in modulating AD pathogenesis. One of the defining features of AD is the accumulation of amyloid-beta (Aß) in the brain, which has a key role in the neurodegenerative cascade. Both testosterone and LH have been shown to modulate CNS Aß accumulation in animal studies, and associations with cerebral amyloid load in human studies have supported this. The underlying mechanisms by which these hormones modulate Aß accumulation and contribute to neurodegeneration are not completely understood, however they have been shown to regulate Aß metabolism, enhance its clearance and alter the processing of its parent molecule, the amyloid precursor protein. This review will discuss underlying mechanisms by which testosterone and LH modulate Aß and provide an update on therapeutic approaches targeting these hormones. |
| first_indexed | 2025-11-14T08:03:36Z |
| format | Journal Article |
| id | curtin-20.500.11937-26923 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:03:36Z |
| publishDate | 2015 |
| publisher | Academic Press Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-269232017-09-13T15:30:00Z The impact of luteinizing hormone and testosterone on beta amyloid (Aß) accumulation: Animal and human clinical studies Verdile, Giuseppe Asih, P. Barron, A. Wahjoepramono, E. Ittner, L. Martins, R. This article is part of a Special Issue "SBN 2014".Hormonal changes associated with ageing have been implicated in the pathogenesis of Alzheimer's disease (AD), the most common form of dementia. Reductions in serum testosterone and increases in luteinizing hormone (LH) are established AD risk factors for dementia in men and have important roles in modulating AD pathogenesis. One of the defining features of AD is the accumulation of amyloid-beta (Aß) in the brain, which has a key role in the neurodegenerative cascade. Both testosterone and LH have been shown to modulate CNS Aß accumulation in animal studies, and associations with cerebral amyloid load in human studies have supported this. The underlying mechanisms by which these hormones modulate Aß accumulation and contribute to neurodegeneration are not completely understood, however they have been shown to regulate Aß metabolism, enhance its clearance and alter the processing of its parent molecule, the amyloid precursor protein. This review will discuss underlying mechanisms by which testosterone and LH modulate Aß and provide an update on therapeutic approaches targeting these hormones. 2015 Journal Article http://hdl.handle.net/20.500.11937/26923 10.1016/j.yhbeh.2015.05.020 Academic Press Inc. restricted |
| spellingShingle | Verdile, Giuseppe Asih, P. Barron, A. Wahjoepramono, E. Ittner, L. Martins, R. The impact of luteinizing hormone and testosterone on beta amyloid (Aß) accumulation: Animal and human clinical studies |
| title | The impact of luteinizing hormone and testosterone on beta amyloid (Aß) accumulation: Animal and human clinical studies |
| title_full | The impact of luteinizing hormone and testosterone on beta amyloid (Aß) accumulation: Animal and human clinical studies |
| title_fullStr | The impact of luteinizing hormone and testosterone on beta amyloid (Aß) accumulation: Animal and human clinical studies |
| title_full_unstemmed | The impact of luteinizing hormone and testosterone on beta amyloid (Aß) accumulation: Animal and human clinical studies |
| title_short | The impact of luteinizing hormone and testosterone on beta amyloid (Aß) accumulation: Animal and human clinical studies |
| title_sort | impact of luteinizing hormone and testosterone on beta amyloid (aß) accumulation: animal and human clinical studies |
| url | http://hdl.handle.net/20.500.11937/26923 |