Role and regulation of phosphatidylinositol 3-kinase ß in platelet integrin α2ß1 signaling

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Role and regulation of phosphatidylinositol 3-kinase ß in platelet integrin α2ß1 signaling

Integrin α2β1–mediated adhesion of human platelets to monomeric type I collagen or to the GFOGER peptide caused a time-dependent activation of PI3K and Akt phosphorylation. This process was abrogated by pharmacologic inhibition of PI3Kβ, but not of PI3Kγ or PI3Kα. Moreover, Akt phosphorylation was u...

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Bibliographic Details
Main Authors:	Consonni, A., Cipolla, L., Guidetti, G., Canobbio, I., Ciraolo, E., Hirsch, E., Falasca, Marco, Okigaki, M., Balduini, C., Torti, M.
Format:	Journal Article
Published:	2012
Online Access:	http://hdl.handle.net/20.500.11937/26852

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