Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition

Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition

Cancer stem cells (CSCs) of head and neck squamous cell carcinoma (HNSCC) are defined by high self-renewal and drug refractory potential. Involvement of Wnt/ß-catenin signaling has been implicated in rapidly cycling cells such as CSCs, and inhibition of the Wnt/ß-catenin pathway is a novel approach...

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Bibliographic Details
Main Authors: Warrier, Sudha, Bhuvanalakshmi, G., Arfuso, Frank, Rajan, G., Milward, M., Dharmarajan, Arunasalam
Format: Journal Article
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/20.500.11937/26825

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