Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images
The aim of this study was to investigate the plaques at the left coronary artery (LCA) and their effect on the haemodynamic and wall shear stress (WSS) in realistic patient models. Three sample patients with left coronary disease were selected based on CT data. The plaques were present at the left a...
| Main Authors: | , , |
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| Format: | Journal Article |
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Springer
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/26711 |
| _version_ | 1848752064069369856 |
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| author | Chaichana, Thanapong Sun, Zhonghua Jewkes, James |
| author_facet | Chaichana, Thanapong Sun, Zhonghua Jewkes, James |
| author_sort | Chaichana, Thanapong |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The aim of this study was to investigate the plaques at the left coronary artery (LCA) and their effect on the haemodynamic and wall shear stress (WSS) in realistic patient models. Three sample patients with left coronary disease were selected based on CT data. The plaques were present at the left anterior descending and left circumflex branches with more than 50 % lumen narrowing. Computational fluid dynamics analysis was used to perform simulation of patient-specific models with realistic physiological conditions that demonstrate in vivo cardiac flow. WSS and blood flow in the LCA were measured during cardiac cycles. Our results showed that WSS was found to increase at the stenotic locations and decrease at pre- and post-plaque locations, whilst the recirculation location was found at post-plaque regions. There is a strong correlation between coronary bifurcation plaques and hemodynamic and WSS changes, based on the realistic coronary disease models. |
| first_indexed | 2025-11-14T08:02:40Z |
| format | Journal Article |
| id | curtin-20.500.11937-26711 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T08:02:40Z |
| publishDate | 2012 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-267112017-09-13T16:07:33Z Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images Chaichana, Thanapong Sun, Zhonghua Jewkes, James The aim of this study was to investigate the plaques at the left coronary artery (LCA) and their effect on the haemodynamic and wall shear stress (WSS) in realistic patient models. Three sample patients with left coronary disease were selected based on CT data. The plaques were present at the left anterior descending and left circumflex branches with more than 50 % lumen narrowing. Computational fluid dynamics analysis was used to perform simulation of patient-specific models with realistic physiological conditions that demonstrate in vivo cardiac flow. WSS and blood flow in the LCA were measured during cardiac cycles. Our results showed that WSS was found to increase at the stenotic locations and decrease at pre- and post-plaque locations, whilst the recirculation location was found at post-plaque regions. There is a strong correlation between coronary bifurcation plaques and hemodynamic and WSS changes, based on the realistic coronary disease models. 2012 Journal Article http://hdl.handle.net/20.500.11937/26711 10.1007/s13246-012-0135-3 Springer fulltext |
| spellingShingle | Chaichana, Thanapong Sun, Zhonghua Jewkes, James Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images |
| title | Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images |
| title_full | Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images |
| title_fullStr | Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images |
| title_full_unstemmed | Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images |
| title_short | Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images |
| title_sort | investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on ct images |
| url | http://hdl.handle.net/20.500.11937/26711 |