Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1

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Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1

The role of signaling pathways in the regulation of cellular iron metabolism is becoming increasingly recognized. Iron chelation is used for the treatment of iron overload but also as a potential strategy for cancer therapy, because iron depletion results in cell cycle arrest and apoptosis. This stu...

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Bibliographic Details
Main Authors:	Yu, Yu, Richardson, D.
Format:	Journal Article
Published:	The American Society for Biochemistry and Molecular Biology Inc 2011
Online Access:	http://hdl.handle.net/20.500.11937/26497

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