Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal ß-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism

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Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal ß-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism

In the present study, we have investigated the effects of the transduction with recombinant adenovirus AdCA-Aralar1 (aspartate-glutamate carrier 1) on the metabolism, function and secretory properties of the glucose- and amino-acid-responsive clonal insulin-secreting cell line BRIN-BD11. Aralar1 ove...

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Bibliographic Details
Main Authors:	Bender, K., Maechler, P., McClenaghan, N., Flatt, P., Newsholme, Philip
Format:	Journal Article
Published:	Portland Press 2009
Online Access:	http://hdl.handle.net/20.500.11937/26084

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