Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model

QR Code

Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model

AIMS: Prostate cancer (PCa) is one of the most commonly diagnosed cancers worldwide. Currently available therapies for metastatic PCa are only marginally effective; hence novel treatment modalities are urgently required. Considerable evidence(s) suggest that deregulated activation of oncogenic trans...

Full description

Bibliographic Details
Main Authors:	Zhang, J., Ahn, K., Kim, C., Shanmugam, M., Siveen, K., Arfuso, Frank, Samym, R., Deivasigamani, A., Lim, L., Wang, L., Goh, B., Kumar, Alan Prem, Hui, K., Sethi, Gautam
Format:	Journal Article
Published:	2016
Online Access:	http://hdl.handle.net/20.500.11937/26083

Similar Items

Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model
by: Shanmugam, M., et al.
Published: (2015)

Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer
by: Shrimali, D., et al.
Published: (2013)

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
by: Shanmugam, M., et al.
Published: (2011)

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model
by: Kim, C., et al.
Published: (2018)

Oleuropein induces apoptosis via abrogating NF-?B activation cascade in estrogen receptor–negative breast cancer cells
by: Liu, L., et al.
Published: (2018)

Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3
by: Dai, X., et al.
Published: (2015)

Targeting PPARy signaling cascade for the prevention and treatment of prostate cancer
by: Sikka, S., et al.
Published: (2012)

Triterpenoids and sesquiterpenoids for prostate cancer therapy
by: Shanmugam, M., et al.
Published: (2016)

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
by: Siveen, K., et al.
Published: (2014)

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model
by: Siveen, K., et al.
Published: (2014)

Targeting transcription factor STAT3 for cancer prevention and therapy.
by: Chai, E., et al.
Published: (2015)

Corrigendum on “Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer” [Cancer Lett. 363 (1) (2015) 28–36]
by: Manu, K., et al.
Published: (2018)

Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-?B signaling cascade in gastric cancer
by: Manu, K., et al.
Published: (2015)

Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade In Vitro and In Vivo
by: Rajendran, P., et al.
Published: (2012)

Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
by: Subramaniam, A., et al.
Published: (2013)

The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies
by: Arora, L., et al.
Published: (2018)

Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis
by: Shanmugam, M., et al.
Published: (2018)

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
by: Siveen, K., et al.
Published: (2013)

A sensitive liquid chromatography-tandem mass spectrometry method for the determination of nimbolide in mouse serum: Application to a preclinical pharmacokinetics study
by: Wang, L., et al.
Published: (2018)

Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer
by: Zhang, J., et al.
Published: (2017)

Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells
by: Siveen, K., et al.
Published: (2014)

High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma
by: Mohd Rohaizad Md Roduan,, et al.
Published: (2015)

Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products
by: Manu, K., et al.
Published: (2013)

Development of a novel azaspirane that targets the Janus Kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo
by: Mohan, C., et al.
Published: (2014)

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: Potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
by: Rajendran, P., et al.
Published: (2011)

Analysis of the intricate relationship between chronic inflammation and cancer
by: Chai, E., et al.
Published: (2015)

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
by: Sethi, G., et al.
Published: (2014)

Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways
by: Shanmugam, M., et al.
Published: (2012)

The theory of abrogation : a critical evaluation
by: Khan, Israr Ahmad
Published: (2006)

Arguments for abrogation in the Qur'an: A critique
by: Khan, Israr Ahmad
Published: (2012)

Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma
by: Subramaniam, A., et al.
Published: (2012)

Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
by: Li, F., et al.
Published: (2015)

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn
by: Shanmugam, M., et al.
Published: (2018)

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn
by: Shanmugam, M., et al.
Published: (2017)

Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinoma
by: Li, F., et al.
Published: (2013)

Arguments for abrogation in the Qur'an: a critical evaluation
by: Khan, Israr Ahmad
Published: (2012)

In Vitro and In Vivo pro-apoptotic and chemosensitizing effects of alpha-tomatine on human prostate adenocarcinoma / Lee Sui Ting
by: Lee, Sui Ting
Published: (2013)

Celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
by: Shanmugam, M., et al.
Published: (2018)

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
by: Shanmugam, M., et al.
Published: (2011)

The role of resveratrol in cancer therapy
by: Ko, J., et al.
Published: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4bsmauirt3jmqnpf38van3f5c5