The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity

The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity

Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to mod...

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Bibliographic Details
Main Authors: Wilkinson, S., Gunosewoyo, Hendra, Barron, M., Boucher, A., McDonnell, M., Turner, P., Morrison, D., Bennett, M., McGregor, I., Rendina, L., Kassiou, M.
Format: Journal Article
Published: American Chemical Society 2014
Subjects:
polycycle
blood-brain barrier
antidepressant
P2X7
Carborane
Online Access:http://hdl.handle.net/20.500.11937/26070

Internet

http://hdl.handle.net/20.500.11937/26070

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