The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity
Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to mod...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
American Chemical Society
2014
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/26070 |
| _version_ | 1848751881440985088 |
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| author | Wilkinson, S. Gunosewoyo, Hendra Barron, M. Boucher, A. McDonnell, M. Turner, P. Morrison, D. Bennett, M. McGregor, I. Rendina, L. Kassiou, M. |
| author_facet | Wilkinson, S. Gunosewoyo, Hendra Barron, M. Boucher, A. McDonnell, M. Turner, P. Morrison, D. Bennett, M. McGregor, I. Rendina, L. Kassiou, M. |
| author_sort | Wilkinson, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to modify CNS activity |
| first_indexed | 2025-11-14T07:59:46Z |
| format | Journal Article |
| id | curtin-20.500.11937-26070 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:59:46Z |
| publishDate | 2014 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-260702018-03-29T09:08:13Z The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity Wilkinson, S. Gunosewoyo, Hendra Barron, M. Boucher, A. McDonnell, M. Turner, P. Morrison, D. Bennett, M. McGregor, I. Rendina, L. Kassiou, M. polycycle blood-brain barrier antidepressant P2X7 Carborane Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to modify CNS activity 2014 Journal Article http://hdl.handle.net/20.500.11937/26070 10.1021/cn500054n American Chemical Society restricted |
| spellingShingle | polycycle blood-brain barrier antidepressant P2X7 Carborane Wilkinson, S. Gunosewoyo, Hendra Barron, M. Boucher, A. McDonnell, M. Turner, P. Morrison, D. Bennett, M. McGregor, I. Rendina, L. Kassiou, M. The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity |
| title | The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity |
| title_full | The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity |
| title_fullStr | The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity |
| title_full_unstemmed | The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity |
| title_short | The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity |
| title_sort | first cns-active carborane: a novel p2x7 receptor antagonist with antidepressant activity |
| topic | polycycle blood-brain barrier antidepressant P2X7 Carborane |
| url | http://hdl.handle.net/20.500.11937/26070 |