The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity
Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to mod...
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Bibliographic Details
| Main Authors: |
Wilkinson, S.,
Gunosewoyo, Hendra,
Barron, M.,
Boucher, A.,
McDonnell, M.,
Turner, P.,
Morrison, D.,
Bennett, M.,
McGregor, I.,
Rendina, L.,
Kassiou, M. |
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| Format: | Journal Article
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| Published: |
American Chemical Society
2014
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| Subjects: | |
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| Online Access: | http://hdl.handle.net/20.500.11937/26070
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