Psychoactive medications and crash involvement requiring hospitalization for older drivers: A population-based study
OBJECTIVES: To determine the association between psychoactive medications and crash risk in drivers aged 60 and older.DESIGN: Retrospective population-based case-crossover study.SETTING: A database study that linked the Western Australian Hospital Morbidity Data System and the Pharmaceutical Benefit...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Wiley-Blackwell Publishing, Inc.
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/25953 |
| _version_ | 1848751849158475776 |
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| author | Meuleners, Lynn Duke, Janine Lee, Andy Palamara, Peter Hildebrand, Janina Ng, Jonathon |
| author_facet | Meuleners, Lynn Duke, Janine Lee, Andy Palamara, Peter Hildebrand, Janina Ng, Jonathon |
| author_sort | Meuleners, Lynn |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | OBJECTIVES: To determine the association between psychoactive medications and crash risk in drivers aged 60 and older.DESIGN: Retrospective population-based case-crossover study.SETTING: A database study that linked the Western Australian Hospital Morbidity Data System and the Pharmaceutical Benefits Scheme.PARTICIPANTS: Six hundred sixteen individuals aged 60 and older who were hospitalized as the result of a motor vehicle crash between 2002 and 2008 in Western Australia.MEASUREMENTS: Hospitalization after a motor vehicle crash.RESULTS: Greater risk for a hospitalization crash was found for older drivers prescribed benzodiazepines (odds ratio (OR) = 5.3, 95% confidence interval (CI) = 3.6–7.8, P<.001), antidepressants (OR = 1.8, 95% CI = 1.0–3.3, P = .04), and opioid analgesics (OR = 1.5, 95% CI = 1.0–2.3, P = .05). Crash risk was significantly greater in men prescribed a benzodiazepine (OR = 6.2, 95% CI = 3.2–12.2, P<.001) or an antidepressant (OR = 2.7, 95% CI = 1.1–6.9, P = .03). Women prescribed benzodiazepines (OR = 4.9, 95% CI = 3.1–7.8, P<.001) or opioid analgesics (OR = 1.8, 95% CI = 1.1–3.0, P = .03) also had a significantly greater crash risk. Subgroup analyses further suggested that drivers with (OR = 4.0, 95% CI = 2.9–8.1, P<.001) and without (OR = 6.0, 95% CI = 3.8–9.5, P < .001) a chronic condition who were prescribed benzodiazepines were at greater crash risk. Drivers with a chronic condition taking antidepressants (OR = 3.4, 95% CI = 1.3–8.5, P = .01) also had a greater crash risk.CONCLUSION: Psychoactive medication usage was associated with greater risk of a motor vehicle crash requiring hospitalization in older drivers. |
| first_indexed | 2025-11-14T07:59:15Z |
| format | Journal Article |
| id | curtin-20.500.11937-25953 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:59:15Z |
| publishDate | 2011 |
| publisher | Wiley-Blackwell Publishing, Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-259532017-09-13T15:23:04Z Psychoactive medications and crash involvement requiring hospitalization for older drivers: A population-based study Meuleners, Lynn Duke, Janine Lee, Andy Palamara, Peter Hildebrand, Janina Ng, Jonathon drivers psychoactive medications older people crash risk aged OBJECTIVES: To determine the association between psychoactive medications and crash risk in drivers aged 60 and older.DESIGN: Retrospective population-based case-crossover study.SETTING: A database study that linked the Western Australian Hospital Morbidity Data System and the Pharmaceutical Benefits Scheme.PARTICIPANTS: Six hundred sixteen individuals aged 60 and older who were hospitalized as the result of a motor vehicle crash between 2002 and 2008 in Western Australia.MEASUREMENTS: Hospitalization after a motor vehicle crash.RESULTS: Greater risk for a hospitalization crash was found for older drivers prescribed benzodiazepines (odds ratio (OR) = 5.3, 95% confidence interval (CI) = 3.6–7.8, P<.001), antidepressants (OR = 1.8, 95% CI = 1.0–3.3, P = .04), and opioid analgesics (OR = 1.5, 95% CI = 1.0–2.3, P = .05). Crash risk was significantly greater in men prescribed a benzodiazepine (OR = 6.2, 95% CI = 3.2–12.2, P<.001) or an antidepressant (OR = 2.7, 95% CI = 1.1–6.9, P = .03). Women prescribed benzodiazepines (OR = 4.9, 95% CI = 3.1–7.8, P<.001) or opioid analgesics (OR = 1.8, 95% CI = 1.1–3.0, P = .03) also had a significantly greater crash risk. Subgroup analyses further suggested that drivers with (OR = 4.0, 95% CI = 2.9–8.1, P<.001) and without (OR = 6.0, 95% CI = 3.8–9.5, P < .001) a chronic condition who were prescribed benzodiazepines were at greater crash risk. Drivers with a chronic condition taking antidepressants (OR = 3.4, 95% CI = 1.3–8.5, P = .01) also had a greater crash risk.CONCLUSION: Psychoactive medication usage was associated with greater risk of a motor vehicle crash requiring hospitalization in older drivers. 2011 Journal Article http://hdl.handle.net/20.500.11937/25953 10.1111/j.1532-5415.2011.03561.x Wiley-Blackwell Publishing, Inc. restricted |
| spellingShingle | drivers psychoactive medications older people crash risk aged Meuleners, Lynn Duke, Janine Lee, Andy Palamara, Peter Hildebrand, Janina Ng, Jonathon Psychoactive medications and crash involvement requiring hospitalization for older drivers: A population-based study |
| title | Psychoactive medications and crash involvement requiring hospitalization for older drivers: A population-based study |
| title_full | Psychoactive medications and crash involvement requiring hospitalization for older drivers: A population-based study |
| title_fullStr | Psychoactive medications and crash involvement requiring hospitalization for older drivers: A population-based study |
| title_full_unstemmed | Psychoactive medications and crash involvement requiring hospitalization for older drivers: A population-based study |
| title_short | Psychoactive medications and crash involvement requiring hospitalization for older drivers: A population-based study |
| title_sort | psychoactive medications and crash involvement requiring hospitalization for older drivers: a population-based study |
| topic | drivers psychoactive medications older people crash risk aged |
| url | http://hdl.handle.net/20.500.11937/25953 |