Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity
The association between P-glycoprotein and Helicobacter pylori infection was explored. We found that P-glycoprotein expression is induced by H. pylori in the upper gastrointestinal tract and influenced by the genetic polymorphism. Further, reduce P-glycoprotein expression is associated with increase...
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| Format: | Thesis |
| Language: | English |
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Curtin University
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/2586 |
| _version_ | 1848743994780024832 |
|---|---|
| author | Omar, Marhanis Salihah |
| author_facet | Omar, Marhanis Salihah |
| author_sort | Omar, Marhanis Salihah |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The association between P-glycoprotein and Helicobacter pylori infection was explored. We found that P-glycoprotein expression is induced by H. pylori in the upper gastrointestinal tract and influenced by the genetic polymorphism. Further, reduce P-glycoprotein expression is associated with increased attachment of the bacteria to epithelial cells. Our results support the hypotheses that high levels of P-glycoprotein expression are protective against gastric cancer and may play a role in H.pylori eradication. |
| first_indexed | 2025-11-14T05:54:25Z |
| format | Thesis |
| id | curtin-20.500.11937-2586 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:54:25Z |
| publishDate | 2013 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-25862017-02-20T06:38:21Z Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity Omar, Marhanis Salihah The association between P-glycoprotein and Helicobacter pylori infection was explored. We found that P-glycoprotein expression is induced by H. pylori in the upper gastrointestinal tract and influenced by the genetic polymorphism. Further, reduce P-glycoprotein expression is associated with increased attachment of the bacteria to epithelial cells. Our results support the hypotheses that high levels of P-glycoprotein expression are protective against gastric cancer and may play a role in H.pylori eradication. 2013 Thesis http://hdl.handle.net/20.500.11937/2586 en Curtin University fulltext |
| spellingShingle | Omar, Marhanis Salihah Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity |
| title | Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity |
| title_full | Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity |
| title_fullStr | Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity |
| title_full_unstemmed | Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity |
| title_short | Interrelationship between Heliobacter pylori and P-glycoprotein: potential role in drug resistance and carcinogenicity |
| title_sort | interrelationship between heliobacter pylori and p-glycoprotein: potential role in drug resistance and carcinogenicity |
| url | http://hdl.handle.net/20.500.11937/2586 |