Prevalence and Subtypes of Mild Cognitive Impairment in Parkinson's Disease.
The current study examined the prevalence and subtypes of Mild Cognitive Impairment (MCI) in an Australian sample of people with Parkinson's Disease (PD). Seventy participants with PD completed neuropsychological assessments of their cognitive performance, using MDS Task Force Level II diagnost...
| Main Authors: | , , |
|---|---|
| Format: | Journal Article |
| Published: |
Nature Publishing Group
2016
|
| Online Access: | http://hdl.handle.net/20.500.11937/25849 |
| _version_ | 1848751821312491520 |
|---|---|
| author | Lawrence, B. Gasson, Natalie Loftus, A. |
| author_facet | Lawrence, B. Gasson, Natalie Loftus, A. |
| author_sort | Lawrence, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The current study examined the prevalence and subtypes of Mild Cognitive Impairment (MCI) in an Australian sample of people with Parkinson's Disease (PD). Seventy participants with PD completed neuropsychological assessments of their cognitive performance, using MDS Task Force Level II diagnostic criteria for PD-MCI. A cut-off score of less than one standard deviation (SD) below normative data determined impaired performance on a neuropsychological test. Of 70 participants, 45 (64%) met Level II diagnostic criteria for PD-MCI. Among those with PD-MCI, 42 (93%) were identified as having multiple domain impairment (28 as amnestic multiple domain and 14 as nonamnestic multiple domain). Single domain impairment was less frequent (2 amnestic/1 nonamnestic). Significant differences were found between the PD-MCI and Normal Cognition groups, across all cognitive domains. Multiple domain cognitive impairment was more frequent than single domain impairment in an Australian sample of people with PD. However, PD-MCI is heterogeneous and current prevalence and subtyping statistics may be an artifact of variable application methods of the criteria (e.g., cut off scores and number of tests). Future longitudinal studies refining the criteria will assist with subtyping the progression of PD-MCI, while identifying individuals who may benefit from pharmacological and nonpharmacological interventions. |
| first_indexed | 2025-11-14T07:58:49Z |
| format | Journal Article |
| id | curtin-20.500.11937-25849 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:58:49Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-258492017-09-13T15:22:40Z Prevalence and Subtypes of Mild Cognitive Impairment in Parkinson's Disease. Lawrence, B. Gasson, Natalie Loftus, A. The current study examined the prevalence and subtypes of Mild Cognitive Impairment (MCI) in an Australian sample of people with Parkinson's Disease (PD). Seventy participants with PD completed neuropsychological assessments of their cognitive performance, using MDS Task Force Level II diagnostic criteria for PD-MCI. A cut-off score of less than one standard deviation (SD) below normative data determined impaired performance on a neuropsychological test. Of 70 participants, 45 (64%) met Level II diagnostic criteria for PD-MCI. Among those with PD-MCI, 42 (93%) were identified as having multiple domain impairment (28 as amnestic multiple domain and 14 as nonamnestic multiple domain). Single domain impairment was less frequent (2 amnestic/1 nonamnestic). Significant differences were found between the PD-MCI and Normal Cognition groups, across all cognitive domains. Multiple domain cognitive impairment was more frequent than single domain impairment in an Australian sample of people with PD. However, PD-MCI is heterogeneous and current prevalence and subtyping statistics may be an artifact of variable application methods of the criteria (e.g., cut off scores and number of tests). Future longitudinal studies refining the criteria will assist with subtyping the progression of PD-MCI, while identifying individuals who may benefit from pharmacological and nonpharmacological interventions. 2016 Journal Article http://hdl.handle.net/20.500.11937/25849 10.1038/srep33929 Nature Publishing Group fulltext |
| spellingShingle | Lawrence, B. Gasson, Natalie Loftus, A. Prevalence and Subtypes of Mild Cognitive Impairment in Parkinson's Disease. |
| title | Prevalence and Subtypes of Mild Cognitive Impairment in Parkinson's Disease. |
| title_full | Prevalence and Subtypes of Mild Cognitive Impairment in Parkinson's Disease. |
| title_fullStr | Prevalence and Subtypes of Mild Cognitive Impairment in Parkinson's Disease. |
| title_full_unstemmed | Prevalence and Subtypes of Mild Cognitive Impairment in Parkinson's Disease. |
| title_short | Prevalence and Subtypes of Mild Cognitive Impairment in Parkinson's Disease. |
| title_sort | prevalence and subtypes of mild cognitive impairment in parkinson's disease. |
| url | http://hdl.handle.net/20.500.11937/25849 |