Nutrient regulation of insulin secretion and ß-cell functional integrity
Pancreatic ß-cells are often referred to as "fuel sensors" as they continually monitor and respond to dietary nutrients, under the modulation of additional neurohormonal signals, in order to secrete insulin to best meet the needs of the organism. ß-cell nutrient sensing requires metabolic...
| Main Authors: | , , |
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| Format: | Journal Article |
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Springer New York LLC
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/25758 |
| _version_ | 1848751797068365824 |
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| author | Newsholme, Philip Gaudel, C. McClenaghan, N. |
| author_facet | Newsholme, Philip Gaudel, C. McClenaghan, N. |
| author_sort | Newsholme, Philip |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pancreatic ß-cells are often referred to as "fuel sensors" as they continually monitor and respond to dietary nutrients, under the modulation of additional neurohormonal signals, in order to secrete insulin to best meet the needs of the organism. ß-cell nutrient sensing requires metabolic activation, resulting in production of stimulus-secretion coupling signals that promote insulin biosynthesis and release. The primary stimulus for insulin secretion is glucose, and islet ß-cells are particularly responsive to this important nutrient secretagogue, It is important to consider individual effects of different classes of nutrient or other physiological or pharmacological agents on metabolism and insulin secretion. However, given that ß-cells are continually exposed to a complex milieu of nutrients and other circulating factors, it is important to also acknowledge and examine the interplay between glucose metabolism and that of the two other primary nutrient classes, the amino acids and fatty acids. It is the mixed nutrient sensing and outputs of glucose, amino and fatty acid metabolism that generate the metabolic coupling factors (MCFs) involved in signaling for insulin exocytosis. Primary MCFs in the ß-cell include ATP, NADPH, glutamate, long chain acyl-CoA and diacylglycerol and are discussed in detail in this article. © Springer Science+Business Media B.V. 2010. |
| first_indexed | 2025-11-14T07:58:26Z |
| format | Journal Article |
| id | curtin-20.500.11937-25758 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:58:26Z |
| publishDate | 2010 |
| publisher | Springer New York LLC |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-257582017-09-13T15:18:08Z Nutrient regulation of insulin secretion and ß-cell functional integrity Newsholme, Philip Gaudel, C. McClenaghan, N. Pancreatic ß-cells are often referred to as "fuel sensors" as they continually monitor and respond to dietary nutrients, under the modulation of additional neurohormonal signals, in order to secrete insulin to best meet the needs of the organism. ß-cell nutrient sensing requires metabolic activation, resulting in production of stimulus-secretion coupling signals that promote insulin biosynthesis and release. The primary stimulus for insulin secretion is glucose, and islet ß-cells are particularly responsive to this important nutrient secretagogue, It is important to consider individual effects of different classes of nutrient or other physiological or pharmacological agents on metabolism and insulin secretion. However, given that ß-cells are continually exposed to a complex milieu of nutrients and other circulating factors, it is important to also acknowledge and examine the interplay between glucose metabolism and that of the two other primary nutrient classes, the amino acids and fatty acids. It is the mixed nutrient sensing and outputs of glucose, amino and fatty acid metabolism that generate the metabolic coupling factors (MCFs) involved in signaling for insulin exocytosis. Primary MCFs in the ß-cell include ATP, NADPH, glutamate, long chain acyl-CoA and diacylglycerol and are discussed in detail in this article. © Springer Science+Business Media B.V. 2010. 2010 Journal Article http://hdl.handle.net/20.500.11937/25758 10.1007/978-90-481-3271-3_6 Springer New York LLC restricted |
| spellingShingle | Newsholme, Philip Gaudel, C. McClenaghan, N. Nutrient regulation of insulin secretion and ß-cell functional integrity |
| title | Nutrient regulation of insulin secretion and ß-cell functional integrity |
| title_full | Nutrient regulation of insulin secretion and ß-cell functional integrity |
| title_fullStr | Nutrient regulation of insulin secretion and ß-cell functional integrity |
| title_full_unstemmed | Nutrient regulation of insulin secretion and ß-cell functional integrity |
| title_short | Nutrient regulation of insulin secretion and ß-cell functional integrity |
| title_sort | nutrient regulation of insulin secretion and ß-cell functional integrity |
| url | http://hdl.handle.net/20.500.11937/25758 |