Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands
Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Pergamon
2008
|
| Online Access: | http://hdl.handle.net/20.500.11937/25636 |
| _version_ | 1848751763956432896 |
|---|---|
| author | Raval, S. Raval, P. Bandyopadhyay, D. Soni, K. Yevale, D. Jogiya, D. Modi, H. Joharapurkar, A. Gandhi, Neha Jain, M. Patel, P. |
| author_facet | Raval, S. Raval, P. Bandyopadhyay, D. Soni, K. Yevale, D. Jogiya, D. Modi, H. Joharapurkar, A. Gandhi, Neha Jain, M. Patel, P. |
| author_sort | Raval, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor ß. © 2008 Elsevier Ltd. All rights reserved. |
| first_indexed | 2025-11-14T07:57:54Z |
| format | Journal Article |
| id | curtin-20.500.11937-25636 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:57:54Z |
| publishDate | 2008 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-256362017-09-13T15:15:34Z Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands Raval, S. Raval, P. Bandyopadhyay, D. Soni, K. Yevale, D. Jogiya, D. Modi, H. Joharapurkar, A. Gandhi, Neha Jain, M. Patel, P. Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor ß. © 2008 Elsevier Ltd. All rights reserved. 2008 Journal Article http://hdl.handle.net/20.500.11937/25636 10.1016/j.bmcl.2008.06.038 Pergamon restricted |
| spellingShingle | Raval, S. Raval, P. Bandyopadhyay, D. Soni, K. Yevale, D. Jogiya, D. Modi, H. Joharapurkar, A. Gandhi, Neha Jain, M. Patel, P. Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands |
| title | Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands |
| title_full | Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands |
| title_fullStr | Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands |
| title_full_unstemmed | Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands |
| title_short | Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands |
| title_sort | design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (tr-ß) selective ligands |
| url | http://hdl.handle.net/20.500.11937/25636 |