Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease

QR Code

Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease

Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent research has provided evidence that insulin resistance and impaired insulin signalling may be a contributory factor to the progression of diabetes...

Full description

Bibliographic Details
Main Authors:	Verdile, Giuseppe, Keane, Kevin, Cruzat, Vinicius, Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R., Fraser, P., Newsholme, Philip
Format:	Journal Article
Published:	2015
Online Access:	http://hdl.handle.net/20.500.11937/25620

Similar Items

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and ß-Cell Dysfunction
by: Keane, Kevin, et al.
Published: (2015)

Nutrient regulation of insulin secretion and action
by: Newsholme, Philip, et al.
Published: (2014)

The bioenergetics of inflammation: insights into obesity and type 2 diabetes
by: Keane, Kevin, et al.
Published: (2017)

Amyloid-ß and islet amyloid pathologies link Alzheimer disease and type 2 diabetes in a transgenic model.
by: Wijesekara, N., et al.
Published: (2017)

Metabolic Regulation of Insulin Secretion
by: Keane, Kevin, et al.
Published: (2014)

The Link Between Diabetes, Glucose Control, and Alzheimer's Disease and Neurodegenerative Diseases
by: Verdile, Giuseppe, et al.
Published: (2019)

Inflammation in Alzheimer's Disease, and Prevention with Antioxidants and Phenolic Compounds – What Are the Most Promising Candidates?
by: Sharman, M., et al.
Published: (2019)

The Role of Luteinizing Hormone in Alzheimer’s Disease
by: Barron, A., et al.
Published: (2010)

β-cell metabolism, insulin production and secretion: Metabolic failure resulting in diabetes
by: Chen, Y., et al.
Published: (2016)

The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid
by: Verdile, Giuseppe, et al.
Published: (2007)

The role of gonadotoprins in Alzheimer’s disease: potential neurodegenerative mechanisms
by: Barron, A., et al.
Published: (2006)

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
by: Xie, Ling, et al.
Published: (2002)

Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic ß-cell bioenergetic parameters and metabolism in BRIN-BD11 cells
by: Rowlands, Jordan, et al.
Published: (2018)

(Dys)Regulation of Insulin Secretion by Macronutrients
by: Newsholme, Philip, et al.
Published: (2015)

Reproductive Hormones Modulate Oxidative Stress in Alzheimer’s Disease
by: Barron, A., et al.
Published: (2006)

Zebrafish as a tool in Alzheimer's disease research
by: Newman, M., et al.
Published: (2011)

Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease
by: Martins, I.j, et al.
Published: (2009)

Glutamine: Metabolism and immune function, supplementation and clinical translation
by: Cruzat, Vinicius, et al.
Published: (2018)

The impact of cryopreservation on human peripheral blood leucocyte bioenergetics
by: Keane, Kevin, et al.
Published: (2015)

Molecular Genetics of Alzheimer's Disease
by: Verdile, Giuseppe, et al.
Published: (2009)

Immunization in Alzheimer’s disease: Naïve hope or realistic clinical potential?
by: Foster, Jonathan, et al.
Published: (2009)

Insulin resistance, inflammation and metabolic syndrome in normal weight and overweight/obese primary school children in Kuala Lumpur
by: Tung, Serene En Hui, et al.
Published: (2018)

Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults
by: Laws, S., et al.
Published: (2017)

Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome
by: Keane, Kevin, et al.
Published: (2016)

Molecular mechanisms of ROS production and oxidative stress in diabetes
by: Newsholme, Philip, et al.
Published: (2016)

Models of Alzheimer’s Disease
by: Chen, M., et al.
Published: (2014)

Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets
by: Chen, Y., et al.
Published: (2016)

Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic ß-cells
by: Keane, D., et al.
Published: (2008)

The Impact of Inflammation on Pancreatic ß-Cell Metabolism, Function and Failure in T1DM and T2DM: Commonalities and Differences
by: Newsholme, Philip, et al.
Published: (2013)

Alanyl-glutamine improves pancreatic ß-cell function following ex vivo inflammatory challenge
by: Cruzat, Vinicius, et al.
Published: (2015)

Effect of chronic hCG administration on Alzheimer's-related cognition and Aß accumulation in PS1KI mice
by: Barron, A., et al.
Published: (2010)

Research criteria for the diagnosis of Alzheimer’s disease: genetic risk factors, blood biomarkers and olfactory dysfunction
by: Foster, Jonathan, et al.
Published: (2008)

Amino acid supplementation and impact on immune function in the context of exercise
by: Cruzat, Vinicius, et al.
Published: (2014)

Mechanisms underlying obesity-related insulin resistance
by: Tewari, Nilanjana
Published: (2016)

The dynamics of CD147 in Alzheimer's disease development and pathology
by: Kanyenda, L., et al.
Published: (2011)

Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise
by: Cruzat, Vinicius, et al.
Published: (2010)

Glutamine and the immune system
by: Cruzat, Vinicius, et al.
Published: (2017)

An introduction to glutamine metabolism
by: Cruzat, Vinicius, et al.
Published: (2017)

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease
by: Goozee, K., et al.
Published: (2015)

Synergy Between Adiposity, Insulin Resistance, Metabolic Risk Factors, and Inflammation in Adolescents
by: Huang, R., et al.
Published: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ae4p9eksvrkgm8h0rbf0d7jpjn