SFRP-4 abrogates Wnt-3a-induced ß-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation

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SFRP-4 abrogates Wnt-3a-induced ß-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation

Background: Conserved Wnt ligands are critical for signalling during development; however, various factors modulate their activity. Among these factors are the Secreted Frizzled-Related Proteins (SFRP). We previously isolated the SFRP-4 gene from an involuting rat mammary gland and later showed that...

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Bibliographic Details
Main Authors:	Constantinou, T., Baumann, F., Lacher, M., Saurer, S., Friis, R., Dharmarajan, Arunasalam
Format:	Journal Article
Published:	2008
Online Access:	http://hdl.handle.net/20.500.11937/25446

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