A transcriptional profile of the decidua in preeclampsia
OBJECTIVE: We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis. STUDY DESIGN: Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/25275 |
| _version_ | 1848751663159967744 |
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| author | Løset, M. Mundal, S. Johnson, M. Fenstad, M. Freed, K. Lian, I. Eide, I. Bjørge, L. Blangero, J. Moses, Eric Austgulen, R. |
| author_facet | Løset, M. Mundal, S. Johnson, M. Fenstad, M. Freed, K. Lian, I. Eide, I. Bjørge, L. Blangero, J. Moses, Eric Austgulen, R. |
| author_sort | Løset, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | OBJECTIVE: We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis. STUDY DESIGN: Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies. Differentially expressed genes were identified and merged into canonical pathways and networks. RESULTS: Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P < .05; false discovery rate, P < .1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated (PLA2G7, HMOX1) genes were identified. Pathway analysis revealed that tryptophan metabolism, endoplasmic reticulum stress, linoleic acid metabolism, notch signaling, fatty acid metabolism, arachidonic acid metabolism, and NRF2-mediated oxidative stress response were overrepresented canonical pathways. CONCLUSION: In the present study single genes, canonical pathways, and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved. |
| first_indexed | 2025-11-14T07:56:18Z |
| format | Journal Article |
| id | curtin-20.500.11937-25275 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:56:18Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-252752018-03-29T09:08:51Z A transcriptional profile of the decidua in preeclampsia Løset, M. Mundal, S. Johnson, M. Fenstad, M. Freed, K. Lian, I. Eide, I. Bjørge, L. Blangero, J. Moses, Eric Austgulen, R. OBJECTIVE: We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis. STUDY DESIGN: Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies. Differentially expressed genes were identified and merged into canonical pathways and networks. RESULTS: Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P < .05; false discovery rate, P < .1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated (PLA2G7, HMOX1) genes were identified. Pathway analysis revealed that tryptophan metabolism, endoplasmic reticulum stress, linoleic acid metabolism, notch signaling, fatty acid metabolism, arachidonic acid metabolism, and NRF2-mediated oxidative stress response were overrepresented canonical pathways. CONCLUSION: In the present study single genes, canonical pathways, and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved. 2011 Journal Article http://hdl.handle.net/20.500.11937/25275 10.1016/j.ajog.2010.08.043 restricted |
| spellingShingle | Løset, M. Mundal, S. Johnson, M. Fenstad, M. Freed, K. Lian, I. Eide, I. Bjørge, L. Blangero, J. Moses, Eric Austgulen, R. A transcriptional profile of the decidua in preeclampsia |
| title | A transcriptional profile of the decidua in preeclampsia |
| title_full | A transcriptional profile of the decidua in preeclampsia |
| title_fullStr | A transcriptional profile of the decidua in preeclampsia |
| title_full_unstemmed | A transcriptional profile of the decidua in preeclampsia |
| title_short | A transcriptional profile of the decidua in preeclampsia |
| title_sort | transcriptional profile of the decidua in preeclampsia |
| url | http://hdl.handle.net/20.500.11937/25275 |