Secreted frizzled related proteins: Implications in cancers
The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
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Elsevier BV
2014
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| Online Access: | 4391 http://hdl.handle.net/20.500.11937/25137 |
| _version_ | 1848751623935885312 |
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| author | Surana, R. Sikka, S. Cai, W. Shin, E. Warrier, Sudha Tan, H. Arfuso, Frank Fox, Simon Dharmarajan, Arunasalam Kumar, A. |
| author_facet | Surana, R. Sikka, S. Cai, W. Shin, E. Warrier, Sudha Tan, H. Arfuso, Frank Fox, Simon Dharmarajan, Arunasalam Kumar, A. |
| author_sort | Surana, R. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant expression of SFRPs has been reported to be associated with numerous cancers. As gene expression of SFRP members is often lost through promoter hypermethylation, inhibition of methylation through the use of epigenetic modifying agents could renew the expression of SFRP members and further antagonize deleterious Wnt signaling. Several reports have described epigenetic silencing of these Wnt signaling antagonists in various human cancers, suggesting their possible role as tumor suppressors. SFRP family members thus come across as potential tools in combating Wnt-driven tumorigenesis. However, little is known about SFRP family members and their role in different cancers. This review comprehensively covers all the available information on the role of SFRP molecules in various human cancers. |
| first_indexed | 2025-11-14T07:55:41Z |
| format | Journal Article |
| id | curtin-20.500.11937-25137 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:55:41Z |
| publishDate | 2014 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-251372018-04-11T05:53:49Z Secreted frizzled related proteins: Implications in cancers Surana, R. Sikka, S. Cai, W. Shin, E. Warrier, Sudha Tan, H. Arfuso, Frank Fox, Simon Dharmarajan, Arunasalam Kumar, A. The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant expression of SFRPs has been reported to be associated with numerous cancers. As gene expression of SFRP members is often lost through promoter hypermethylation, inhibition of methylation through the use of epigenetic modifying agents could renew the expression of SFRP members and further antagonize deleterious Wnt signaling. Several reports have described epigenetic silencing of these Wnt signaling antagonists in various human cancers, suggesting their possible role as tumor suppressors. SFRP family members thus come across as potential tools in combating Wnt-driven tumorigenesis. However, little is known about SFRP family members and their role in different cancers. This review comprehensively covers all the available information on the role of SFRP molecules in various human cancers. 2014 Journal Article http://hdl.handle.net/20.500.11937/25137 10.1016/j.bbcan.2013.11.004 4391 Elsevier BV restricted |
| spellingShingle | Surana, R. Sikka, S. Cai, W. Shin, E. Warrier, Sudha Tan, H. Arfuso, Frank Fox, Simon Dharmarajan, Arunasalam Kumar, A. Secreted frizzled related proteins: Implications in cancers |
| title | Secreted frizzled related proteins: Implications in cancers |
| title_full | Secreted frizzled related proteins: Implications in cancers |
| title_fullStr | Secreted frizzled related proteins: Implications in cancers |
| title_full_unstemmed | Secreted frizzled related proteins: Implications in cancers |
| title_short | Secreted frizzled related proteins: Implications in cancers |
| title_sort | secreted frizzled related proteins: implications in cancers |
| url | 4391 http://hdl.handle.net/20.500.11937/25137 |