Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials
Here we have demonstrated a solventless plasma-based process that integrates low-cost, high throughput,high reproducibility and ecofriendly process for the functionalization of the next-generationpoint-of-care device platforms. Amine functionalities were deposited by plasma-enhanced chemicalvapour d...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal Article |
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Elsevier
2010
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/25059 |
| _version_ | 1848751601991286784 |
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| author | Volcke, C. Gandhiraman, R. Gubala, V. Raj, J. Cummins, T. Fonder, G. Nooney, R. Mekhalif, Z. Herzog, G. Daniels, S. Arrigan, Damien Cafolla, A. Williams, D. |
| author_facet | Volcke, C. Gandhiraman, R. Gubala, V. Raj, J. Cummins, T. Fonder, G. Nooney, R. Mekhalif, Z. Herzog, G. Daniels, S. Arrigan, Damien Cafolla, A. Williams, D. |
| author_sort | Volcke, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Here we have demonstrated a solventless plasma-based process that integrates low-cost, high throughput,high reproducibility and ecofriendly process for the functionalization of the next-generationpoint-of-care device platforms. Amine functionalities were deposited by plasma-enhanced chemicalvapour deposition (PECVD) using a new precursor. The influence of the plasma RF power and the deposition time on surfacial properties, as well as their effect on the reactivity and content of amino groups was investigated. The key process determinants were to have a sufficient power in the plasma to activate and partially fragment the monomer but not too much as to lose the reactive amine functionality, and sufficient deposition time to develop a reactive layer but not to consume or erode the amine reactivity. An immunoassay performed using human immunoglobulin (IgG) as a model analyte showed an improvement of the detection limit by two orders of magnitude beyond that obtained using devices activated by liquid-phase reaction. |
| first_indexed | 2025-11-14T07:55:20Z |
| format | Journal Article |
| id | curtin-20.500.11937-25059 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:55:20Z |
| publishDate | 2010 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-250592019-02-19T05:35:40Z Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials Volcke, C. Gandhiraman, R. Gubala, V. Raj, J. Cummins, T. Fonder, G. Nooney, R. Mekhalif, Z. Herzog, G. Daniels, S. Arrigan, Damien Cafolla, A. Williams, D. Biosensors Polymer Nanoparticle deposition DNA Plasma-enhanced chemical vapour Immunoassay Here we have demonstrated a solventless plasma-based process that integrates low-cost, high throughput,high reproducibility and ecofriendly process for the functionalization of the next-generationpoint-of-care device platforms. Amine functionalities were deposited by plasma-enhanced chemicalvapour deposition (PECVD) using a new precursor. The influence of the plasma RF power and the deposition time on surfacial properties, as well as their effect on the reactivity and content of amino groups was investigated. The key process determinants were to have a sufficient power in the plasma to activate and partially fragment the monomer but not too much as to lose the reactive amine functionality, and sufficient deposition time to develop a reactive layer but not to consume or erode the amine reactivity. An immunoassay performed using human immunoglobulin (IgG) as a model analyte showed an improvement of the detection limit by two orders of magnitude beyond that obtained using devices activated by liquid-phase reaction. 2010 Journal Article http://hdl.handle.net/20.500.11937/25059 10.1016/j.bios.2009.12.034 Elsevier fulltext |
| spellingShingle | Biosensors Polymer Nanoparticle deposition DNA Plasma-enhanced chemical vapour Immunoassay Volcke, C. Gandhiraman, R. Gubala, V. Raj, J. Cummins, T. Fonder, G. Nooney, R. Mekhalif, Z. Herzog, G. Daniels, S. Arrigan, Damien Cafolla, A. Williams, D. Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials |
| title | Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials |
| title_full | Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials |
| title_fullStr | Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials |
| title_full_unstemmed | Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials |
| title_short | Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials |
| title_sort | reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials |
| topic | Biosensors Polymer Nanoparticle deposition DNA Plasma-enhanced chemical vapour Immunoassay |
| url | http://hdl.handle.net/20.500.11937/25059 |