Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer
© 2014 John Wiley & Sons, Inc. The different branches of the Wnt signaling pathway were first characterized in developmental contexts, but in recent times, each branch has been implicated in tumor growth and progression. This chapter exemplifies this link between development and cancer by focusi...
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| Format: | Book Chapter |
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Wiley Blackwell
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/24997 |
| _version_ | 1848751584165494784 |
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| author | Fifis, T. Tran, B. Schwab, R. Johanson, T. Warner, N. Barker, N. Vincan, Elizabeth |
| author_facet | Fifis, T. Tran, B. Schwab, R. Johanson, T. Warner, N. Barker, N. Vincan, Elizabeth |
| author_sort | Fifis, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2014 John Wiley & Sons, Inc. The different branches of the Wnt signaling pathway were first characterized in developmental contexts, but in recent times, each branch has been implicated in tumor growth and progression. This chapter exemplifies this link between development and cancer by focusing on two Wnt-driven cancers, colorectal cancer (CRC) and hepatocellular carcinoma (HCC). It focuses on the processes of epithelial-to-mesenchymal transition (EMT) and the reverse transition, mesenchymal-to-epithelial transition (MET), both fundamental mechanisms of tumor metastasis and morphogenesis. HCC shares many parallels with CRC with respect to the involvement of Wnt signaling in cancer initiation and progression. |
| first_indexed | 2025-11-14T07:55:03Z |
| format | Book Chapter |
| id | curtin-20.500.11937-24997 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:55:03Z |
| publishDate | 2014 |
| publisher | Wiley Blackwell |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-249972017-09-13T15:20:00Z Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer Fifis, T. Tran, B. Schwab, R. Johanson, T. Warner, N. Barker, N. Vincan, Elizabeth © 2014 John Wiley & Sons, Inc. The different branches of the Wnt signaling pathway were first characterized in developmental contexts, but in recent times, each branch has been implicated in tumor growth and progression. This chapter exemplifies this link between development and cancer by focusing on two Wnt-driven cancers, colorectal cancer (CRC) and hepatocellular carcinoma (HCC). It focuses on the processes of epithelial-to-mesenchymal transition (EMT) and the reverse transition, mesenchymal-to-epithelial transition (MET), both fundamental mechanisms of tumor metastasis and morphogenesis. HCC shares many parallels with CRC with respect to the involvement of Wnt signaling in cancer initiation and progression. 2014 Book Chapter http://hdl.handle.net/20.500.11937/24997 10.1002/9781118444122.ch24 Wiley Blackwell restricted |
| spellingShingle | Fifis, T. Tran, B. Schwab, R. Johanson, T. Warner, N. Barker, N. Vincan, Elizabeth Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer |
| title | Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer |
| title_full | Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer |
| title_fullStr | Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer |
| title_full_unstemmed | Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer |
| title_short | Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer |
| title_sort | wnt signaling regulation of tissue architecture (emt and met) and morphogenesis: consequences for colorectal and liver cancer |
| url | http://hdl.handle.net/20.500.11937/24997 |