The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults
S100B is a calcium binding peptide produced predominantly by astroglial cells in the central nervous system. S100B paradoxically has neurotrophic and apoptotic effects, dependent on extracellular concentration. This study investigated the relationship between serum S100B levels and neuropsychologica...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Frontiers Research Foundation
2013
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/24957 |
| _version_ | 1848751573269741568 |
|---|---|
| author | Lam, Virginie Albrecht, Matthew Takechi, Ryusuke Giles, C. James, Anthony Foster, Jonathan Mamo, John |
| author_facet | Lam, Virginie Albrecht, Matthew Takechi, Ryusuke Giles, C. James, Anthony Foster, Jonathan Mamo, John |
| author_sort | Lam, Virginie |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | S100B is a calcium binding peptide produced predominantly by astroglial cells in the central nervous system. S100B paradoxically has neurotrophic and apoptotic effects, dependent on extracellular concentration. This study investigated the relationship between serum S100B levels and neuropsychological performance across a range of cognitive domains in healthy older aged adults. A cohort of 219 participants between the ages of 43 and 84 years (141 female) were recruited. Subjects provided a fasting blood sample for S100B measurement (Mean = 0.24 ng/mL, SD = 0.14) and completed a battery of neuropsychological tests. S100B concentrations (both with and without the covariates of age and sex) were positively associated with the following measures of cognitive performance: digit-symbol coding, Stroop test, and measures of verbal ability. The results from this study show that serum S100B is positively associated with better cognitive performance in healthy older adults. |
| first_indexed | 2025-11-14T07:54:52Z |
| format | Journal Article |
| id | curtin-20.500.11937-24957 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:54:52Z |
| publishDate | 2013 |
| publisher | Frontiers Research Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-249572017-09-13T15:20:31Z The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults Lam, Virginie Albrecht, Matthew Takechi, Ryusuke Giles, C. James, Anthony Foster, Jonathan Mamo, John Alzheimer’s disease neuropsychological measures S100B Bayesian analysis neuro-inflammation S100B is a calcium binding peptide produced predominantly by astroglial cells in the central nervous system. S100B paradoxically has neurotrophic and apoptotic effects, dependent on extracellular concentration. This study investigated the relationship between serum S100B levels and neuropsychological performance across a range of cognitive domains in healthy older aged adults. A cohort of 219 participants between the ages of 43 and 84 years (141 female) were recruited. Subjects provided a fasting blood sample for S100B measurement (Mean = 0.24 ng/mL, SD = 0.14) and completed a battery of neuropsychological tests. S100B concentrations (both with and without the covariates of age and sex) were positively associated with the following measures of cognitive performance: digit-symbol coding, Stroop test, and measures of verbal ability. The results from this study show that serum S100B is positively associated with better cognitive performance in healthy older adults. 2013 Journal Article http://hdl.handle.net/20.500.11937/24957 10.3389/fnagi.2013.00061 Frontiers Research Foundation fulltext |
| spellingShingle | Alzheimer’s disease neuropsychological measures S100B Bayesian analysis neuro-inflammation Lam, Virginie Albrecht, Matthew Takechi, Ryusuke Giles, C. James, Anthony Foster, Jonathan Mamo, John The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults |
| title | The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults |
| title_full | The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults |
| title_fullStr | The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults |
| title_full_unstemmed | The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults |
| title_short | The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults |
| title_sort | serum concentration of the calcium binding protein s100b is positively associated with cognitive performance in older adults |
| topic | Alzheimer’s disease neuropsychological measures S100B Bayesian analysis neuro-inflammation |
| url | http://hdl.handle.net/20.500.11937/24957 |