The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers

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The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers

1. Caco-2 cells were used to compare P-gp mediated efflux and passive permeability using bidirectional transport of 11 antihistamines. An efflux ratio >2 indicated active efflux, with PSC833 and GF120918 used as functional P-gp inhibitors. 2. Antihistamines were measured directly by HPLC or LC/MS...

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Bibliographic Details
Main Authors:	Crowe, Andrew, Wright, Cameron
Format:	Journal Article
Published:	Informa Healthcare 2011
Online Access:	http://hdl.handle.net/20.500.11937/24956

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