The relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control
Mild thiamin deficiency is prevalent in diabetes, and high dose thiamin ameliorates some diabetic complications, but there are no definitive studies addressing thiamin intake, diabetes control and thiamin status in diabetes. Subjects were 113 people with diabetes (58 type 1, 55 type 2), 43 with and...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
Curtin University
2008
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/248 |
| _version_ | 1848743325235937280 |
|---|---|
| author | Vindedzis, Sally Ann |
| author_facet | Vindedzis, Sally Ann |
| author_sort | Vindedzis, Sally Ann |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Mild thiamin deficiency is prevalent in diabetes, and high dose thiamin ameliorates some diabetic complications, but there are no definitive studies addressing thiamin intake, diabetes control and thiamin status in diabetes. Subjects were 113 people with diabetes (58 type 1, 55 type 2), 43 with and 70 without thiamin supplementation. Dietary thiamin was estimated by 24-hour recall, diabetes control by HbA1c. Age, BMI, albumin excretion, activity level and smoking status did not correlate with red cell thiamin (RCT) in either group. RCT correlated with serum thiamin (ST) (p < 0.01). In those unsupplemented, adequate dietary thiamin did not ensure normal RCT, with 15.7 % of subjects below the reference range. Supplementation to intake > 4 mg/d, was significantly associated with normal RCT (p = 0.028), with 97.7% of supplemented subjects having normal RCT. Supplementation was also significantly associated with elevated serum thiamin 24 hours post supplementation, contrary to other reports. HbA1c was not significantly associated with RCT. Conclusions: In diabetes, adequate dietary thiamin does not ensure normal red cell thiamin, but supplementation to > 4 mg/day does, raising questions about actual thiamin requirements in diabetes and supporting evidence that thiamin deficiency in diabetes is not primarily due to dietary deficiency. Diabetes control was not significantly related to thiamin status. |
| first_indexed | 2025-11-14T05:43:46Z |
| format | Thesis |
| id | curtin-20.500.11937-248 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:43:46Z |
| publishDate | 2008 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-2482017-02-20T06:41:35Z The relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control Vindedzis, Sally Ann diabetic complications diabetes thiamin deficiency diabetes control thiamin intake thiamin status in diabetes Mild thiamin deficiency is prevalent in diabetes, and high dose thiamin ameliorates some diabetic complications, but there are no definitive studies addressing thiamin intake, diabetes control and thiamin status in diabetes. Subjects were 113 people with diabetes (58 type 1, 55 type 2), 43 with and 70 without thiamin supplementation. Dietary thiamin was estimated by 24-hour recall, diabetes control by HbA1c. Age, BMI, albumin excretion, activity level and smoking status did not correlate with red cell thiamin (RCT) in either group. RCT correlated with serum thiamin (ST) (p < 0.01). In those unsupplemented, adequate dietary thiamin did not ensure normal RCT, with 15.7 % of subjects below the reference range. Supplementation to intake > 4 mg/d, was significantly associated with normal RCT (p = 0.028), with 97.7% of supplemented subjects having normal RCT. Supplementation was also significantly associated with elevated serum thiamin 24 hours post supplementation, contrary to other reports. HbA1c was not significantly associated with RCT. Conclusions: In diabetes, adequate dietary thiamin does not ensure normal red cell thiamin, but supplementation to > 4 mg/day does, raising questions about actual thiamin requirements in diabetes and supporting evidence that thiamin deficiency in diabetes is not primarily due to dietary deficiency. Diabetes control was not significantly related to thiamin status. 2008 Thesis http://hdl.handle.net/20.500.11937/248 en Curtin University fulltext |
| spellingShingle | diabetic complications diabetes thiamin deficiency diabetes control thiamin intake thiamin status in diabetes Vindedzis, Sally Ann The relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control |
| title | The relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control |
| title_full | The relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control |
| title_fullStr | The relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control |
| title_full_unstemmed | The relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control |
| title_short | The relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control |
| title_sort | relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control |
| topic | diabetic complications diabetes thiamin deficiency diabetes control thiamin intake thiamin status in diabetes |
| url | http://hdl.handle.net/20.500.11937/248 |