A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation
A one-pot, three-component, microwave-assisted reaction of polysubstituted 5-aminopyrazoles, triethyl orthoformate, and a series of cyclic secondary amines was developed and successfully employed for the synthesis of novel N-pyrazolylformamidines. Under catalyst-free conditions, the reaction proceed...
| Main Authors: | , , |
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| Format: | Journal Article |
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Georg Thieme Verlag
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/24652 |
| _version_ | 1848751490184773632 |
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| author | Lim, F. Luna, G. Dolzhenko, Anton |
| author_facet | Lim, F. Luna, G. Dolzhenko, Anton |
| author_sort | Lim, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A one-pot, three-component, microwave-assisted reaction of polysubstituted 5-aminopyrazoles, triethyl orthoformate, and a series of cyclic secondary amines was developed and successfully employed for the synthesis of novel N-pyrazolylformamidines. Under catalyst-free conditions, the reaction proceeded in a chemo- and regioselective manner, resulting in the formation of unsymmetric formamidines, which were isolated in high yields and purity. Some of the prepared compounds were found to inhibit interleukin-17 secretion in phenotypic in vitro assays. |
| first_indexed | 2025-11-14T07:53:33Z |
| format | Journal Article |
| id | curtin-20.500.11937-24652 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:53:33Z |
| publishDate | 2016 |
| publisher | Georg Thieme Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-246522017-09-13T15:11:56Z A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation Lim, F. Luna, G. Dolzhenko, Anton A one-pot, three-component, microwave-assisted reaction of polysubstituted 5-aminopyrazoles, triethyl orthoformate, and a series of cyclic secondary amines was developed and successfully employed for the synthesis of novel N-pyrazolylformamidines. Under catalyst-free conditions, the reaction proceeded in a chemo- and regioselective manner, resulting in the formation of unsymmetric formamidines, which were isolated in high yields and purity. Some of the prepared compounds were found to inhibit interleukin-17 secretion in phenotypic in vitro assays. 2016 Journal Article http://hdl.handle.net/20.500.11937/24652 10.1055/s-0035-1561616 Georg Thieme Verlag restricted |
| spellingShingle | Lim, F. Luna, G. Dolzhenko, Anton A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation |
| title | A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation |
| title_full | A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation |
| title_fullStr | A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation |
| title_full_unstemmed | A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation |
| title_short | A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation |
| title_sort | new, one-pot, multicomponent synthesis of bioactive n -pyrazolylformamidines under microwave irradiation |
| url | http://hdl.handle.net/20.500.11937/24652 |