The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women
Objective: To elucidate whether the chronic consumption of dealcoholised red wine (DRW) (polyphenol-rich component) and/or red wine (RW) improves vascular function in hypercholesterolaemic postmenopausal women. Design, subjects and intervention: A randomised parallel-arm study. Forty-five hyperchole...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
Nature Publishing Group
2006
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| Online Access: | http://hdl.handle.net/20.500.11937/24563 |
| _version_ | 1848751465981542400 |
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| author | Naissides, Mary Pal, Sebely Mamo, John James, Anthony Dhaliwal, Satvinder |
| author_facet | Naissides, Mary Pal, Sebely Mamo, John James, Anthony Dhaliwal, Satvinder |
| author_sort | Naissides, Mary |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objective: To elucidate whether the chronic consumption of dealcoholised red wine (DRW) (polyphenol-rich component) and/or red wine (RW) improves vascular function in hypercholesterolaemic postmenopausal women. Design, subjects and intervention: A randomised parallel-arm study. Forty-five hypercholesterolaemic postmenopausal women were randomised into either water, DRW or RW group for 6 weeks following a 4 week washout. Fasting measures of central haemodynamic parameters, arterial wave reflection and endothelial nitric oxide were taken at 0 and 6 weeks. Setting: Clinic in the School of Public Health, Curtin University. Results: There were no significant between group differences in arterial stiffness as measured by augmentation index (AIx) and augmentation pressure (AP). However, a significant within group decrease in AIx (-9%, P=0.02) and AP (-12%, P=0.02) was observed following DRW consumption. No significant changes were observed in central haemodynamic parameters and endothelial nitric oxide levels following DRW and RW consumption, compared to water.Conclusions: Neither the chronic consumption of DRW nor RW improved markers of arterial stiffness, compared to control. However, the significant within group improvements in these indices following the consumption of DRW cannot be overlooked and warrant further investigation. |
| first_indexed | 2025-11-14T07:53:10Z |
| format | Journal Article |
| id | curtin-20.500.11937-24563 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:53:10Z |
| publishDate | 2006 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-245632017-09-13T15:52:51Z The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women Naissides, Mary Pal, Sebely Mamo, John James, Anthony Dhaliwal, Satvinder Objective: To elucidate whether the chronic consumption of dealcoholised red wine (DRW) (polyphenol-rich component) and/or red wine (RW) improves vascular function in hypercholesterolaemic postmenopausal women. Design, subjects and intervention: A randomised parallel-arm study. Forty-five hypercholesterolaemic postmenopausal women were randomised into either water, DRW or RW group for 6 weeks following a 4 week washout. Fasting measures of central haemodynamic parameters, arterial wave reflection and endothelial nitric oxide were taken at 0 and 6 weeks. Setting: Clinic in the School of Public Health, Curtin University. Results: There were no significant between group differences in arterial stiffness as measured by augmentation index (AIx) and augmentation pressure (AP). However, a significant within group decrease in AIx (-9%, P=0.02) and AP (-12%, P=0.02) was observed following DRW consumption. No significant changes were observed in central haemodynamic parameters and endothelial nitric oxide levels following DRW and RW consumption, compared to water.Conclusions: Neither the chronic consumption of DRW nor RW improved markers of arterial stiffness, compared to control. However, the significant within group improvements in these indices following the consumption of DRW cannot be overlooked and warrant further investigation. 2006 Journal Article http://hdl.handle.net/20.500.11937/24563 10.1038/sj.ejcn.1602377 Nature Publishing Group unknown |
| spellingShingle | Naissides, Mary Pal, Sebely Mamo, John James, Anthony Dhaliwal, Satvinder The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women |
| title | The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women |
| title_full | The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women |
| title_fullStr | The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women |
| title_full_unstemmed | The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women |
| title_short | The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women |
| title_sort | effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women |
| url | http://hdl.handle.net/20.500.11937/24563 |