Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children
OBJECTIVE: The goal was to determine the number of breaths required to inhale salbutamol from different spacers/valved holding chambers (VHCs). METHODS: Breathing patterns were recorded for 2- to 7-year-old children inhaling placebo from 4 different spacers/VHCs and were simulated by a flow generato...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Published: |
American Academy of Pediatrics
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/24524 |
| _version_ | 1848751454688378880 |
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| author | Schultz, A. Le Souëf, T. Venter, A. Zhang, Guicheng Devadason, S. Le Souëf, P. |
| author_facet | Schultz, A. Le Souëf, T. Venter, A. Zhang, Guicheng Devadason, S. Le Souëf, P. |
| author_sort | Schultz, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | OBJECTIVE: The goal was to determine the number of breaths required to inhale salbutamol from different spacers/valved holding chambers (VHCs). METHODS: Breathing patterns were recorded for 2- to 7-year-old children inhaling placebo from 4 different spacers/VHCs and were simulated by a flow generator. Drug delivery with different numbers of tidal breaths and with a single maximal breath was compared. RESULTS: With tidal breathing, mean inhalation volumes were large, ranging from 384 mL to 445 mL. Mean values for drug delivery with an Aerochamber Plus (Trudell, London, Canada) were 40% (95% confidence interval [CI]: 34%-46%) and 41% (95% CI: 36%-47%) of the total dose with 2 and 9 tidal breaths, respectively. Mean drug delivery values with these breath numbers with a Funhaler (Visiomed, Perth, Australia) were 39% (95% CI: 34%-43%) and 38% (95% CI: 35%-42%), respectively. With a Volumatic (GlaxoSmithKline, Melbourne, Australia), mean drug delivery values with 2 and 9 tidal breaths were 37% (95% CI: 33%-41%) and 43% (95% CI: 40%-46%), respectively (P = .02); there was no significant difference in drug delivery with 3 versus 9 tidal breaths. With the modified soft drink bottle, drug delivery. Drug delivery was not improved with a single maximal breath with any device. CONCLUSION: For young children, tidal breaths through a spacer/VHC were much larger than expected. Two tidal breaths were adequate for small-volume VHCs and a 500-mL modified soft drink bottle, and 3 tidal breaths were adequate for the larger Volumatic VHC. Copyright © 2010 by the American Academy of Pediatrics. |
| first_indexed | 2025-11-14T07:52:59Z |
| format | Journal Article |
| id | curtin-20.500.11937-24524 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:52:59Z |
| publishDate | 2010 |
| publisher | American Academy of Pediatrics |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-245242017-09-13T15:07:52Z Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children Schultz, A. Le Souëf, T. Venter, A. Zhang, Guicheng Devadason, S. Le Souëf, P. OBJECTIVE: The goal was to determine the number of breaths required to inhale salbutamol from different spacers/valved holding chambers (VHCs). METHODS: Breathing patterns were recorded for 2- to 7-year-old children inhaling placebo from 4 different spacers/VHCs and were simulated by a flow generator. Drug delivery with different numbers of tidal breaths and with a single maximal breath was compared. RESULTS: With tidal breathing, mean inhalation volumes were large, ranging from 384 mL to 445 mL. Mean values for drug delivery with an Aerochamber Plus (Trudell, London, Canada) were 40% (95% confidence interval [CI]: 34%-46%) and 41% (95% CI: 36%-47%) of the total dose with 2 and 9 tidal breaths, respectively. Mean drug delivery values with these breath numbers with a Funhaler (Visiomed, Perth, Australia) were 39% (95% CI: 34%-43%) and 38% (95% CI: 35%-42%), respectively. With a Volumatic (GlaxoSmithKline, Melbourne, Australia), mean drug delivery values with 2 and 9 tidal breaths were 37% (95% CI: 33%-41%) and 43% (95% CI: 40%-46%), respectively (P = .02); there was no significant difference in drug delivery with 3 versus 9 tidal breaths. With the modified soft drink bottle, drug delivery. Drug delivery was not improved with a single maximal breath with any device. CONCLUSION: For young children, tidal breaths through a spacer/VHC were much larger than expected. Two tidal breaths were adequate for small-volume VHCs and a 500-mL modified soft drink bottle, and 3 tidal breaths were adequate for the larger Volumatic VHC. Copyright © 2010 by the American Academy of Pediatrics. 2010 Journal Article http://hdl.handle.net/20.500.11937/24524 10.1542/peds.2010-1377 American Academy of Pediatrics restricted |
| spellingShingle | Schultz, A. Le Souëf, T. Venter, A. Zhang, Guicheng Devadason, S. Le Souëf, P. Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children |
| title | Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children |
| title_full | Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children |
| title_fullStr | Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children |
| title_full_unstemmed | Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children |
| title_short | Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children |
| title_sort | aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children |
| url | http://hdl.handle.net/20.500.11937/24524 |