Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-ß-catenin-mediated intestinal tumor growth and regeneration

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-ß-catenin-mediated intestinal tumor growth and regeneration

Copyright © 2014 American Association for the Advancement of Science. All Rights Reserved. Most colon cancers arise from somatic mutations in the tumor suppressor gene APC (adenomatous polyposis coli), and these mutations cause constitutive activation of the Wnt-to-ß-catenin pathway in the intestina...

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Main Authors: Phesse, T., Buchert, M., Stuart, E., Flanagan, D., Faux, M., Afshar-Sterle, S., Walker, F., Zhang, H., Nowell, C., Jorissen, R., Tan, C., Hirokawa, Y., Eissmann, M., Poh, A., Malaterre, J., Pearson, H., Kirsch, D., Provero, P., Poli, V., Ramsay, R., Sieber, O., Burgess, A., Huszar, D., Vincan, Elizabeth, Ernst, M.
Format: Journal Article
Published: American Association for the Advancement of Science 2014
Online Access:http://hdl.handle.net/20.500.11937/24519

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