Melanoma biomolecules: Independently identified but functionally intertwined
The majority of patients diagnosed with melanoma present with thin lesions and generally these patients have a good prognosis. However, 5% of patients with early melanoma (<1 mm thick) will have recurrence and die within 10 years, despite no evidence of local or metastatic spread at the time of d...
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| Format: | Journal Article |
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Frontiers
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/24459 |
| _version_ | 1848751435448057856 |
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| author | Dye, Danielle Medic, S. Ziman, M. Coombe, Deirdre |
| author_facet | Dye, Danielle Medic, S. Ziman, M. Coombe, Deirdre |
| author_sort | Dye, Danielle |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The majority of patients diagnosed with melanoma present with thin lesions and generally these patients have a good prognosis. However, 5% of patients with early melanoma (<1 mm thick) will have recurrence and die within 10 years, despite no evidence of local or metastatic spread at the time of diagnosis. Thus, there is a need for additional prognostic markers to help identify those patients that may be at risk of recurrent disease. Many studies and several meta-analyses have compared gene and protein expression in melanocytes, naevi, primary, and metastatic melanoma in an attempt to find informative prognostic markers for these patients. However, although a large number of putative biomarkers have been described, few of these molecules are informative when used in isolation. The best approach is likely to involve a combination of molecules. We believe one approach could be to analyze the expression of a group of interacting proteins that regulate different aspects of the metastatic pathway. This is because a primary lesion expressing proteins involved in multiple stages of metastasis may be more likely to lead to secondary disease than one that does not. This review focuses on five putative biomarkers – melanoma cell adhesion molecule (MCAM), galectin-3 (gal-3), matrix metalloproteinase 2 (MMP-2), chondroitin sulfate proteoglycan 4 (CSPG4), and paired box 3 (PAX3). The goal is to provide context around what is known about the contribution of these biomarkers to melanoma biology and metastasis. Although each of these molecules have been independently identified as likely biomarkers, it is clear from our analyses that each are closely linked with each other, with intertwined roles in melanoma biology. |
| first_indexed | 2025-11-14T07:52:41Z |
| format | Journal Article |
| id | curtin-20.500.11937-24459 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:52:41Z |
| publishDate | 2013 |
| publisher | Frontiers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-244592017-09-13T15:08:25Z Melanoma biomolecules: Independently identified but functionally intertwined Dye, Danielle Medic, S. Ziman, M. Coombe, Deirdre biomarker galectin-3 CSPG4 Pax3 melanoma CD146 MMP2 The majority of patients diagnosed with melanoma present with thin lesions and generally these patients have a good prognosis. However, 5% of patients with early melanoma (<1 mm thick) will have recurrence and die within 10 years, despite no evidence of local or metastatic spread at the time of diagnosis. Thus, there is a need for additional prognostic markers to help identify those patients that may be at risk of recurrent disease. Many studies and several meta-analyses have compared gene and protein expression in melanocytes, naevi, primary, and metastatic melanoma in an attempt to find informative prognostic markers for these patients. However, although a large number of putative biomarkers have been described, few of these molecules are informative when used in isolation. The best approach is likely to involve a combination of molecules. We believe one approach could be to analyze the expression of a group of interacting proteins that regulate different aspects of the metastatic pathway. This is because a primary lesion expressing proteins involved in multiple stages of metastasis may be more likely to lead to secondary disease than one that does not. This review focuses on five putative biomarkers – melanoma cell adhesion molecule (MCAM), galectin-3 (gal-3), matrix metalloproteinase 2 (MMP-2), chondroitin sulfate proteoglycan 4 (CSPG4), and paired box 3 (PAX3). The goal is to provide context around what is known about the contribution of these biomarkers to melanoma biology and metastasis. Although each of these molecules have been independently identified as likely biomarkers, it is clear from our analyses that each are closely linked with each other, with intertwined roles in melanoma biology. 2013 Journal Article http://hdl.handle.net/20.500.11937/24459 10.3389/fonc.2013.00252 Frontiers fulltext |
| spellingShingle | biomarker galectin-3 CSPG4 Pax3 melanoma CD146 MMP2 Dye, Danielle Medic, S. Ziman, M. Coombe, Deirdre Melanoma biomolecules: Independently identified but functionally intertwined |
| title | Melanoma biomolecules: Independently identified but functionally intertwined |
| title_full | Melanoma biomolecules: Independently identified but functionally intertwined |
| title_fullStr | Melanoma biomolecules: Independently identified but functionally intertwined |
| title_full_unstemmed | Melanoma biomolecules: Independently identified but functionally intertwined |
| title_short | Melanoma biomolecules: Independently identified but functionally intertwined |
| title_sort | melanoma biomolecules: independently identified but functionally intertwined |
| topic | biomarker galectin-3 CSPG4 Pax3 melanoma CD146 MMP2 |
| url | http://hdl.handle.net/20.500.11937/24459 |