Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent
Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2012
|
| Online Access: | http://hdl.handle.net/20.500.11937/24294 |
| _version_ | 1848751388425715712 |
|---|---|
| author | Liu, Lihong Huang, Y. Riduan, S. Gao, S. Yang, Y. Fan, W. Zhang, Y. |
| author_facet | Liu, Lihong Huang, Y. Riduan, S. Gao, S. Yang, Y. Fan, W. Zhang, Y. |
| author_sort | Liu, Lihong |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans, while displaying minimal hemolysis (HC50/MIC values over 3000) and a very high therapeutic index of 37 for killing S. aureus under inflammatory conditions in vivo. |
| first_indexed | 2025-11-14T07:51:56Z |
| format | Journal Article |
| id | curtin-20.500.11937-24294 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:51:56Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-242942017-09-13T15:08:24Z Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent Liu, Lihong Huang, Y. Riduan, S. Gao, S. Yang, Y. Fan, W. Zhang, Y. Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans, while displaying minimal hemolysis (HC50/MIC values over 3000) and a very high therapeutic index of 37 for killing S. aureus under inflammatory conditions in vivo. 2012 Journal Article http://hdl.handle.net/20.500.11937/24294 10.1016/j.biomaterials.2012.08.006 restricted |
| spellingShingle | Liu, Lihong Huang, Y. Riduan, S. Gao, S. Yang, Y. Fan, W. Zhang, Y. Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent |
| title | Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent |
| title_full | Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent |
| title_fullStr | Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent |
| title_full_unstemmed | Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent |
| title_short | Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent |
| title_sort | main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent |
| url | http://hdl.handle.net/20.500.11937/24294 |