Five-Year Decline in Estimated Glomerular Filtration Rate Associated With a Higher Risk of Renal Disease and Atherosclerotic Vascular Disease Clinical Events in Elderly Women
Background: Estimated glomerular filtration rate (eGFR) has been demonstrated to predict atherosclerotic vascular disease (ASVD)-associated clinical events independent of traditional vascular risk factors. Recent studies have demonstrated that eGFR decline over time may improve prediction of ASVD-as...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
Oxford University Press
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/24153 |
| _version_ | 1848751350044688384 |
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| author | Lim, W Lewis, J Wong, G Dogra, G Zhu, K Lim, E Dhaliwal, Satvinder Prince, R |
| author_facet | Lim, W Lewis, J Wong, G Dogra, G Zhu, K Lim, E Dhaliwal, Satvinder Prince, R |
| author_sort | Lim, W |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Estimated glomerular filtration rate (eGFR) has been demonstrated to predict atherosclerotic vascular disease (ASVD)-associated clinical events independent of traditional vascular risk factors. Recent studies have demonstrated that eGFR decline over time may improve prediction of ASVD-associated mortality risk in chronic kidney disease (CKD) patients. Aim: The aim of this study is to evaluate the association between 5-year change in eGFR with renal disease and ASVD-associated clinical events. Design: Prospective observational study. Methods: A total of 1012 women over the age of 70 years from the Calcium Intake Fracture Outcome Study were included. Baseline characteristics including baseline and 5-year creatinine, participants’ comorbidities and complete verified 10-year records for ASVD and renal disease-associated hospitalization and/or mortality were obtained using the Western Australian Data Linkage System. Results: Participants were stratified according to annual rate of eGFR change in quartiles [≤−1.2 (first quartile), >−1.2 to 0.1 (second quartile), >0.1–1.7 (third quartile) and >1.7 ml/min/1.73 m2/year (fourth quartile)]. In the adjusted model, compared with participants in the fourth quartile, those in the first and/or second quartiles of annual eGFR change had significantly higher risk of renal disease and/or ASVD-associated clinical events. However, the association with renal clinical events was more apparent in participants with baseline eGFR of <60 ml/min/1.73 m2. Conclusion: The results of this study suggest that the inclusion of long-term eGFR change over time might augment prognostication for renal disease and ASVD-associated clinical events in elderly women. |
| first_indexed | 2025-11-14T07:51:19Z |
| format | Journal Article |
| id | curtin-20.500.11937-24153 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:51:19Z |
| publishDate | 2013 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-241532017-09-13T15:08:24Z Five-Year Decline in Estimated Glomerular Filtration Rate Associated With a Higher Risk of Renal Disease and Atherosclerotic Vascular Disease Clinical Events in Elderly Women Lim, W Lewis, J Wong, G Dogra, G Zhu, K Lim, E Dhaliwal, Satvinder Prince, R Background: Estimated glomerular filtration rate (eGFR) has been demonstrated to predict atherosclerotic vascular disease (ASVD)-associated clinical events independent of traditional vascular risk factors. Recent studies have demonstrated that eGFR decline over time may improve prediction of ASVD-associated mortality risk in chronic kidney disease (CKD) patients. Aim: The aim of this study is to evaluate the association between 5-year change in eGFR with renal disease and ASVD-associated clinical events. Design: Prospective observational study. Methods: A total of 1012 women over the age of 70 years from the Calcium Intake Fracture Outcome Study were included. Baseline characteristics including baseline and 5-year creatinine, participants’ comorbidities and complete verified 10-year records for ASVD and renal disease-associated hospitalization and/or mortality were obtained using the Western Australian Data Linkage System. Results: Participants were stratified according to annual rate of eGFR change in quartiles [≤−1.2 (first quartile), >−1.2 to 0.1 (second quartile), >0.1–1.7 (third quartile) and >1.7 ml/min/1.73 m2/year (fourth quartile)]. In the adjusted model, compared with participants in the fourth quartile, those in the first and/or second quartiles of annual eGFR change had significantly higher risk of renal disease and/or ASVD-associated clinical events. However, the association with renal clinical events was more apparent in participants with baseline eGFR of <60 ml/min/1.73 m2. Conclusion: The results of this study suggest that the inclusion of long-term eGFR change over time might augment prognostication for renal disease and ASVD-associated clinical events in elderly women. 2013 Journal Article http://hdl.handle.net/20.500.11937/24153 10.1093/qjmed/hct043 Oxford University Press unknown |
| spellingShingle | Lim, W Lewis, J Wong, G Dogra, G Zhu, K Lim, E Dhaliwal, Satvinder Prince, R Five-Year Decline in Estimated Glomerular Filtration Rate Associated With a Higher Risk of Renal Disease and Atherosclerotic Vascular Disease Clinical Events in Elderly Women |
| title | Five-Year Decline in Estimated Glomerular Filtration Rate Associated With a Higher Risk of Renal Disease and Atherosclerotic Vascular Disease Clinical Events in Elderly Women |
| title_full | Five-Year Decline in Estimated Glomerular Filtration Rate Associated With a Higher Risk of Renal Disease and Atherosclerotic Vascular Disease Clinical Events in Elderly Women |
| title_fullStr | Five-Year Decline in Estimated Glomerular Filtration Rate Associated With a Higher Risk of Renal Disease and Atherosclerotic Vascular Disease Clinical Events in Elderly Women |
| title_full_unstemmed | Five-Year Decline in Estimated Glomerular Filtration Rate Associated With a Higher Risk of Renal Disease and Atherosclerotic Vascular Disease Clinical Events in Elderly Women |
| title_short | Five-Year Decline in Estimated Glomerular Filtration Rate Associated With a Higher Risk of Renal Disease and Atherosclerotic Vascular Disease Clinical Events in Elderly Women |
| title_sort | five-year decline in estimated glomerular filtration rate associated with a higher risk of renal disease and atherosclerotic vascular disease clinical events in elderly women |
| url | http://hdl.handle.net/20.500.11937/24153 |