Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans
Bacteriocins are attracting increased attention as an alternative to classic antibiotics in the fight against infectious disease and multidrug resistant pathogens. Bacillus subtilis strain MMA7 isolated from the marine sponge Haliclona simulans displays a broad spectrum antimicrobial activity, which...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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MDPI Community & Outreach
2013
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/23902 |
| _version_ | 1848751280886906880 |
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| author | Phelan, Robert Barret, Matthieu Cotter, Paul O’Connor, Paula Chen, Rui Morrissey, John Dobson, Alan O'Gara, Fergal Barbosa, Teresa |
| author_facet | Phelan, Robert Barret, Matthieu Cotter, Paul O’Connor, Paula Chen, Rui Morrissey, John Dobson, Alan O'Gara, Fergal Barbosa, Teresa |
| author_sort | Phelan, Robert |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Bacteriocins are attracting increased attention as an alternative to classic antibiotics in the fight against infectious disease and multidrug resistant pathogens. Bacillus subtilis strain MMA7 isolated from the marine sponge Haliclona simulans displays a broad spectrum antimicrobial activity, which includes Gram-positive and Gram-negative pathogens, as well as several pathogenic Candida species. This activity is in part associated with a newly identified lantibiotic, herein named as subtilomycin. The proposed biosynthetic cluster is composed of six genes, including protein-coding genes for LanB-like dehydratase and LanC-like cyclase modification enzymes, characteristic of the class I lantibiotics. The subtilomycin biosynthetic cluster in B. subtilis strain MMA7 is found in place of the sporulation killing factor (skf) operon, reported in many B. subtilis isolates and involved in a bacterial cannibalistic behaviour intended to delay sporulation. The presence of the subtilomycin biosynthetic cluster appears to be widespread amongst B. subtilis strains isolated from different shallow and deep water marine sponges. Subtilomycin possesses several desirable industrial and pharmaceutical physicochemical properties, including activity over a wide pH range, thermal resistance and water solubility. Additionally, the production of the lantibiotic subtilomycin could be a desirable property should B. subtilis strain MMA7 be employed as a probiotic in aquaculture applications. |
| first_indexed | 2025-11-14T07:50:13Z |
| format | Journal Article |
| id | curtin-20.500.11937-23902 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:50:13Z |
| publishDate | 2013 |
| publisher | MDPI Community & Outreach |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-239022017-09-13T14:01:06Z Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans Phelan, Robert Barret, Matthieu Cotter, Paul O’Connor, Paula Chen, Rui Morrissey, John Dobson, Alan O'Gara, Fergal Barbosa, Teresa subtilomycin Bacillus subtilis marine sponge lantibiotic antimicrobial Bacteriocins are attracting increased attention as an alternative to classic antibiotics in the fight against infectious disease and multidrug resistant pathogens. Bacillus subtilis strain MMA7 isolated from the marine sponge Haliclona simulans displays a broad spectrum antimicrobial activity, which includes Gram-positive and Gram-negative pathogens, as well as several pathogenic Candida species. This activity is in part associated with a newly identified lantibiotic, herein named as subtilomycin. The proposed biosynthetic cluster is composed of six genes, including protein-coding genes for LanB-like dehydratase and LanC-like cyclase modification enzymes, characteristic of the class I lantibiotics. The subtilomycin biosynthetic cluster in B. subtilis strain MMA7 is found in place of the sporulation killing factor (skf) operon, reported in many B. subtilis isolates and involved in a bacterial cannibalistic behaviour intended to delay sporulation. The presence of the subtilomycin biosynthetic cluster appears to be widespread amongst B. subtilis strains isolated from different shallow and deep water marine sponges. Subtilomycin possesses several desirable industrial and pharmaceutical physicochemical properties, including activity over a wide pH range, thermal resistance and water solubility. Additionally, the production of the lantibiotic subtilomycin could be a desirable property should B. subtilis strain MMA7 be employed as a probiotic in aquaculture applications. 2013 Journal Article http://hdl.handle.net/20.500.11937/23902 10.3390/md11061878 MDPI Community & Outreach unknown |
| spellingShingle | subtilomycin Bacillus subtilis marine sponge lantibiotic antimicrobial Phelan, Robert Barret, Matthieu Cotter, Paul O’Connor, Paula Chen, Rui Morrissey, John Dobson, Alan O'Gara, Fergal Barbosa, Teresa Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans |
| title | Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans |
| title_full | Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans |
| title_fullStr | Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans |
| title_full_unstemmed | Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans |
| title_short | Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans |
| title_sort | subtilomycin: a new lantibiotic from bacillus subtilis strain mma7 isolated from the marine sponge haliclona simulans |
| topic | subtilomycin Bacillus subtilis marine sponge lantibiotic antimicrobial |
| url | http://hdl.handle.net/20.500.11937/23902 |