The association between resting heart rate, cardiovascular disease and mortality: Evidence from 112,680 men and women in 12 cohorts
Background: Multiple studies have examined the relationship between heart rate and mortality; however, there are discrepancies in results. Our aim was to describe the relationship between resting heart rate (RHR) and both major cardiovascular (CV) outcomes, as well as all-cause mortality in the Asia...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
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2014
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| Online Access: | http://hdl.handle.net/20.500.11937/23854 |
| _version_ | 1848751266672410624 |
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| author | Woodward, M. Webster, R. Murakami, Y. Barzi, F. Lam, T. Fang, X. Suh, I. Batty, G. Huxley, Rachel Rodgers, A. |
| author_facet | Woodward, M. Webster, R. Murakami, Y. Barzi, F. Lam, T. Fang, X. Suh, I. Batty, G. Huxley, Rachel Rodgers, A. |
| author_sort | Woodward, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Multiple studies have examined the relationship between heart rate and mortality; however, there are discrepancies in results. Our aim was to describe the relationship between resting heart rate (RHR) and both major cardiovascular (CV) outcomes, as well as all-cause mortality in the Asia-Pacific region. Design and methods: Individual data from 112,680 subjects in 12 cohort studies were pooled and analysed using Cox models, stratified by study and sex, and adjusted for age and systolic blood pressure. Results: During a mean 7.4 years follow-up, 6086 deaths and 2726 fatal or nonfatal CVevents were recorded. There was a continuous, increasing association between having a RHR above approximately 65 beats/min and the risk of both CV and all-cause mortality, yet there was no evidence of associations below this threshold. The hazard ratio (95% CI) comparing the extreme quarters of RHR (80 v <65 beats/min) was 1.44 (1.291.60) for CV and 1.54 (1.431.66) for total mortality. These associations were not materially changed by adjustment for other risk factors and exclusion of the first 2 years of follow-up. Hazard ratios of a similar magnitude were found for ischemic and hemorrhagic stroke, but the hazard ratio for heart failure was higher (2.08, 95% CI 1.074.06) and for Coronary Heart Disease (CHD) was lower (1.11, 95% CI 0.931.31) than for stroke. Conclusions: RHR of above 65 beats/min has a strong independent effect on premature mortality and stroke, but a lesser effect on CHD. Lifestyle and pharmaceutical regimens to reduce RHR may be beneficial for people with moderate to high levels of RHR. © The European Society of Cardiology 2012. |
| first_indexed | 2025-11-14T07:50:00Z |
| format | Journal Article |
| id | curtin-20.500.11937-23854 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:50:00Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-238542017-09-13T14:00:15Z The association between resting heart rate, cardiovascular disease and mortality: Evidence from 112,680 men and women in 12 cohorts Woodward, M. Webster, R. Murakami, Y. Barzi, F. Lam, T. Fang, X. Suh, I. Batty, G. Huxley, Rachel Rodgers, A. Background: Multiple studies have examined the relationship between heart rate and mortality; however, there are discrepancies in results. Our aim was to describe the relationship between resting heart rate (RHR) and both major cardiovascular (CV) outcomes, as well as all-cause mortality in the Asia-Pacific region. Design and methods: Individual data from 112,680 subjects in 12 cohort studies were pooled and analysed using Cox models, stratified by study and sex, and adjusted for age and systolic blood pressure. Results: During a mean 7.4 years follow-up, 6086 deaths and 2726 fatal or nonfatal CVevents were recorded. There was a continuous, increasing association between having a RHR above approximately 65 beats/min and the risk of both CV and all-cause mortality, yet there was no evidence of associations below this threshold. The hazard ratio (95% CI) comparing the extreme quarters of RHR (80 v <65 beats/min) was 1.44 (1.291.60) for CV and 1.54 (1.431.66) for total mortality. These associations were not materially changed by adjustment for other risk factors and exclusion of the first 2 years of follow-up. Hazard ratios of a similar magnitude were found for ischemic and hemorrhagic stroke, but the hazard ratio for heart failure was higher (2.08, 95% CI 1.074.06) and for Coronary Heart Disease (CHD) was lower (1.11, 95% CI 0.931.31) than for stroke. Conclusions: RHR of above 65 beats/min has a strong independent effect on premature mortality and stroke, but a lesser effect on CHD. Lifestyle and pharmaceutical regimens to reduce RHR may be beneficial for people with moderate to high levels of RHR. © The European Society of Cardiology 2012. 2014 Journal Article http://hdl.handle.net/20.500.11937/23854 10.1177/2047487312452501 restricted |
| spellingShingle | Woodward, M. Webster, R. Murakami, Y. Barzi, F. Lam, T. Fang, X. Suh, I. Batty, G. Huxley, Rachel Rodgers, A. The association between resting heart rate, cardiovascular disease and mortality: Evidence from 112,680 men and women in 12 cohorts |
| title | The association between resting heart rate, cardiovascular disease and mortality: Evidence from 112,680 men and women in 12 cohorts |
| title_full | The association between resting heart rate, cardiovascular disease and mortality: Evidence from 112,680 men and women in 12 cohorts |
| title_fullStr | The association between resting heart rate, cardiovascular disease and mortality: Evidence from 112,680 men and women in 12 cohorts |
| title_full_unstemmed | The association between resting heart rate, cardiovascular disease and mortality: Evidence from 112,680 men and women in 12 cohorts |
| title_short | The association between resting heart rate, cardiovascular disease and mortality: Evidence from 112,680 men and women in 12 cohorts |
| title_sort | association between resting heart rate, cardiovascular disease and mortality: evidence from 112,680 men and women in 12 cohorts |
| url | http://hdl.handle.net/20.500.11937/23854 |