Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox-sensitive genes in human kidney proximal tubular cells

QR Code

Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox-sensitive genes in human kidney proximal tubular cells

Key points: Cystine is a disulphide amino acid that is normally generated in the lysosomes by the breakdown of cystine-containing proteins. Previously, we demonstrated that lysosomal cystine accumulation in kidney proximal tubular epithelial cells (PTECs) dramatically reduced glutathione (GSH) level...

Full description

Bibliographic Details
Main Authors:	Sumayao, R., McEvoy, B., Newsholme, Philip, McMorrow, T.
Format:	Journal Article
Published:	Wiley-Blackwell Publishing Ltd. 2016
Online Access:	http://hdl.handle.net/20.500.11937/23800

Similar Items

Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line
by: Sumayao, Rodolpho, et al.
Published: (2013)

Cystine accumulation attenuates insulin release from the pancreatic beta-cell due to elevated oxidative stress and decreased ATP levels.
by: McEvoy, B., et al.
Published: (2015)

Toxicodynamic Evaluation of a Cisplatin-Chondroitin Sulfate Complex Using a Perfused Kidney and Human Proximal Tubular Cells
by: Zhang, J., et al.
Published: (2011)

Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks
by: Hlinka, Jaroslav, et al.
Published: (2010)

Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level
by: Shtukenberg, A., et al.
Published: (2015)

Comparative study on conductivity using Polarization and Depolarization Current (PDC) test for HV Insulation
by: Jamaii, N. A. M., et al.
Published: (2011)

Molecular interaction analysis to design new drug candidates for Lysosomal storage disease
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2011)

A uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionate accumulates in proximal tubular cells and induces cell damage through increasing oxidative stress
by: Miyamoto, Y., et al.
Published: (2012)

Bcl-2: A prime regulator of mitochondrial redox metabolism in cancer cells
by: Low, I., et al.
Published: (2011)

Mitochondrial redox modulation of NLRP3 inflammasome in differentiated THP-1 cells
by: Abas, Razif, et al.
Published: (2019)

The significance of tubular and glomerular proteinuria in critically ill patients with severe acute kidney injury
by: Lim, Christopher Thiam Seong, et al.
Published: (2014)

Edible bird nest protects the kidney from gentamicin induced acute tubular necrosis
by: Lim, Christopher Thiam Seong, et al.
Published: (2021)

Transportation and Accumulation of Redox Active Species at the Buried Interfaces of Plasticized Membrane Electrodes
by: Sohail, M., et al.
Published: (2015)

Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung
by: Yakubu, D.P., et al.
Published: (2007)

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with acidic stores (lysosomes) in the heart
by: Aston, Daniel, et al.
Published: (2017)

Heat shock factor 4 regulates lens epithelial cell homeostasis by working with lysosome and anti-apoptosis pathways
by: Cui, X., et al.
Published: (2016)

Innovations in our Understanding of The Development, Maintenance, and Treatment of Social Anxiety: Introduction to The Special Issue
by: McEvoy, Peter
Published: (2016)

Repetitive negative thinking as a transdiagnostic predictor of depression and anxiety symptoms in youth
by: McEvoy, Peter
Published: (2017)

Innovations in our Understanding of the Development, Maintenance, and Treatment of Social Anxiety: Introduction to the Special Issue: Editorial for the Special Issue on Social Anxiety Disorder
by: McEvoy, Peter
Published: (2016)

Common Versus Unique Variance Across Measures of Worry and Rumination: Predictive Utility and Mediational Models for Anxiety and Depression
by: McEvoy, Peter, et al.
Published: (2013)

Cognitive behavioural group therapy for social phobia with or without attention training: A controlled trial
by: McEvoy, Peter, et al.
Published: (2009)

Social anxiety disorder: looking back and moving forward
by: Hyett, Matthew, et al.
Published: (2018)

To be sure, to be sure: intolerance of uncertainty mediates symptoms of various anxiety disorders and depression
by: McEvoy, Peter, et al.
Published: (2012)

Changes in intolerance of uncertainty during cognitive behavior group therapy for social phobia
by: Mahoney, A., et al.
Published: (2012)

Imagery-enhanced cognitive behavioural group therapy for social anxiety disorder: A pilot study
by: McEvoy, Peter, et al.
Published: (2014)

The effect of comorbid substance use disorders on treatment outcome for anxiety disorders
by: McEvoy, Peter, et al.
Published: (2008)

A test of the core process account of psychopathology in a heterogenous clinical sample of anxiety and depression: A case of the blind men and the elephant?
by: Mansell, W., et al.
Published: (2016)

Achieving certainty about the structure of intolerance of uncertainty in a treatment-seeking sample with anxiety and depression
by: McEvoy, Peter, et al.
Published: (2011)

The wonder and angst of exploring the unknown: Introduction to the special issue on intolerance of uncertainty
by: McEvoy, Peter, et al.
Published: (2016)

Trait versus situation-specific intolerance of uncertainty in a clinical sample with anxiety and depressive disorders
by: Mahoney, A., et al.
Published: (2012)

A transdiagnostic examination of intolerance of uncertainty across anxiety and depressive disorders
by: Mahoney, A., et al.
Published: (2012)

Intolerance of uncertainty and negative metacognitive beliefs as transdiagnostic mediators of repetitive negative thinking in a clinical sample with anxiety disorders
by: McEvoy, Peter, et al.
Published: (2013)

The public/private confluence: administrative law and community housing
by: McEvoy, K., et al.
Published: (2010)

Continuous transesterification for tubular reactor
by: Lau, Kun Lu
Published: (2015)

Redox decoupling and redox budgets: Conceptual tools for thestudy of earth systems
by: Evans, Katy
Published: (2006)

A Bifactor Model of Intolerance of Uncertainty in Undergraduate and Clinical Samples: Do We Need to Reconsider the Two-Factor Model?
by: Shihata, S., et al.
Published: (2018)

Efficacy of brief guided self-help cognitive behavioral treatment for perfectionism in reducing perinatal depression and anxiety: a randomized controlled trial
by: Lowndes, T., et al.
Published: (2018)

From impact factors to Altmetrics: What numbers are important in publishing your paper?
by: McEvoy, N.L., et al.
Published: (2023)

Pathways from uncertainty to anxiety: An evaluation of a hierarchical model of trait and disorder-specific intolerance of uncertainty on anxiety disorder symptoms
by: Shihata, S., et al.
Published: (2017)

Epidemiology of anxiety disorders in the Australian general population: findings of the 2007 Australian National Survey of Mental Health and Wellbeing
by: McEvoy, Peter, et al.
Published: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2aq9dg794n87rg4fpk7fsvt04e