A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate

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A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate

Background: Owing to its role in cancer, the phosphoinositide 3-kinase (PI3K)/Akt pathway is an attractive target for therapeutic intervention. We previously reported that the inhibition of Akt by inositol 1,3,4,5,6- pentakisphosphate (InsP5) results in anti-tumour properties. To further develop thi...

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Bibliographic Details
Main Authors:	Falasca, Marco, Chiozzotto, D., Godage, H., Mazzoletti, M., Riley, A., Previdi, S., Potter, B., Broggini, M., Maffucci, T.
Format:	Journal Article
Published:	Nature Publishing Group 2010
Online Access:	http://hdl.handle.net/20.500.11937/23657

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