Bioreactor design for tendon/ligament engineering
Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic stud...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
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Mary Ann Liebert Inc Publishers
2012
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/23593 |
| _version_ | 1848751194115145728 |
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| author | Wang, T. Gardiner, B. Lin, Z. Rubenson, J. Kirk, Thomas Wang, A. Xu, J. Smith, D. Lloyd, D. Zheng, M. |
| author_facet | Wang, T. Gardiner, B. Lin, Z. Rubenson, J. Kirk, Thomas Wang, A. Xu, J. Smith, D. Lloyd, D. Zheng, M. |
| author_sort | Wang, T. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments. |
| first_indexed | 2025-11-14T07:48:51Z |
| format | Journal Article |
| id | curtin-20.500.11937-23593 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:48:51Z |
| publishDate | 2012 |
| publisher | Mary Ann Liebert Inc Publishers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-235932018-03-29T09:06:48Z Bioreactor design for tendon/ligament engineering Wang, T. Gardiner, B. Lin, Z. Rubenson, J. Kirk, Thomas Wang, A. Xu, J. Smith, D. Lloyd, D. Zheng, M. tendons bioreactor ligaments Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments. 2012 Journal Article http://hdl.handle.net/20.500.11937/23593 10.1089/ten.teb.2012.0295 Mary Ann Liebert Inc Publishers restricted |
| spellingShingle | tendons bioreactor ligaments Wang, T. Gardiner, B. Lin, Z. Rubenson, J. Kirk, Thomas Wang, A. Xu, J. Smith, D. Lloyd, D. Zheng, M. Bioreactor design for tendon/ligament engineering |
| title | Bioreactor design for tendon/ligament engineering |
| title_full | Bioreactor design for tendon/ligament engineering |
| title_fullStr | Bioreactor design for tendon/ligament engineering |
| title_full_unstemmed | Bioreactor design for tendon/ligament engineering |
| title_short | Bioreactor design for tendon/ligament engineering |
| title_sort | bioreactor design for tendon/ligament engineering |
| topic | tendons bioreactor ligaments |
| url | http://hdl.handle.net/20.500.11937/23593 |