Characterization of a unique conformational epitope on free immunoglobulin kappa light chains that is recognized by an antibody with therapeutic potential

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Characterization of a unique conformational epitope on free immunoglobulin kappa light chains that is recognized by an antibody with therapeutic potential

The murine mAb, K-1-21, recognizes a conformational epitope expressed on free Ig kappa light chains (FκLCs) and also on cell membrane-associated FκLCs found on kappa myeloma cells. This has led to the development of a chimeric version of K-1-21, MDX-1097, which is being assessed in a Phase II clinic...

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Bibliographic Details
Main Authors:	Hutchinson, A., Alexova, R., Bockhorni, V., Ramsland, Paul, Jones, D., Jennings, C., Broady, K., Edmundson, A., Raison, R.
Format:	Journal Article
Published:	2011
Online Access:	http://hdl.handle.net/20.500.11937/23510

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