Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies
The potential protective effects of vitamin D against cutaneous carcinogenesis are still poorly understood. The inhibition, by vitamin D, of various cancers in in vitro and in vivo models has triggered detailed investigation of vitamin D effects on neoplastic behavior. Recent studies highlight that...
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| Format: | Journal Article |
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John Wiley & Sons, Inc.
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/23500 |
| _version_ | 1848751168828735488 |
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| author | Nemazannikova, N. Antonas, K. Dass, Crispin |
| author_facet | Nemazannikova, N. Antonas, K. Dass, Crispin |
| author_sort | Nemazannikova, N. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The potential protective effects of vitamin D against cutaneous carcinogenesis are still poorly understood. The inhibition, by vitamin D, of various cancers in in vitro and in vivo models has triggered detailed investigation of vitamin D effects on neoplastic behavior. Recent studies highlight that such neoplastic features as the tumor microenvironment, angiogenesis, DNA mutagenesis, and apoptosis are all connected to vitamin D metabolic pathways. This review discusses these connections. Vitamin D modulation of the cell cycle, DNA repair and apoptosis via its receptors (VDRs) may have a suppressive effect on skin cancer as some studies suggest. The regulation of multiple tumor signaling pathways by vitamin D may have an implication in cutaneous carcinogenesis and tumor progression to malignancy. |
| first_indexed | 2025-11-14T07:48:27Z |
| format | Journal Article |
| id | curtin-20.500.11937-23500 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:48:27Z |
| publishDate | 2014 |
| publisher | John Wiley & Sons, Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-235002017-09-13T13:59:02Z Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies Nemazannikova, N. Antonas, K. Dass, Crispin NMSC tumor angiogenesis vitamin D cancer The potential protective effects of vitamin D against cutaneous carcinogenesis are still poorly understood. The inhibition, by vitamin D, of various cancers in in vitro and in vivo models has triggered detailed investigation of vitamin D effects on neoplastic behavior. Recent studies highlight that such neoplastic features as the tumor microenvironment, angiogenesis, DNA mutagenesis, and apoptosis are all connected to vitamin D metabolic pathways. This review discusses these connections. Vitamin D modulation of the cell cycle, DNA repair and apoptosis via its receptors (VDRs) may have a suppressive effect on skin cancer as some studies suggest. The regulation of multiple tumor signaling pathways by vitamin D may have an implication in cutaneous carcinogenesis and tumor progression to malignancy. 2014 Journal Article http://hdl.handle.net/20.500.11937/23500 10.1002/mc.21999 John Wiley & Sons, Inc. restricted |
| spellingShingle | NMSC tumor angiogenesis vitamin D cancer Nemazannikova, N. Antonas, K. Dass, Crispin Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies |
| title | Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies |
| title_full | Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies |
| title_fullStr | Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies |
| title_full_unstemmed | Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies |
| title_short | Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies |
| title_sort | vitamin d: metabolism, molecular mechanisms, and mutations to malignancies |
| topic | NMSC tumor angiogenesis vitamin D cancer |
| url | http://hdl.handle.net/20.500.11937/23500 |