(Dys)Regulation of Insulin Secretion by Macronutrients
Pancreatic β-cells are often referred to as “fuel sensors” as they continually monitor and respond to dietary nutrients, under the modulation of additional neurohormonal signals, in order to secrete insulin to best meet the needs of the organism. β-Cell nutrient sensing requires metabolic activation...
| Main Authors: | , , , |
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| Format: | Book Chapter |
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Springer
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/23498 |
| _version_ | 1848751168533037056 |
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| author | Newsholme, Philip Keane, Kevin Gaudel, C. McClenaghan, N. |
| author2 | Md. Shahidul Islam |
| author_facet | Md. Shahidul Islam Newsholme, Philip Keane, Kevin Gaudel, C. McClenaghan, N. |
| author_sort | Newsholme, Philip |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pancreatic β-cells are often referred to as “fuel sensors” as they continually monitor and respond to dietary nutrients, under the modulation of additional neurohormonal signals, in order to secrete insulin to best meet the needs of the organism. β-Cell nutrient sensing requires metabolic activation, resulting in production of stimulus-secretion coupling signals that promote insulin biosynthesis and release. The primary stimulus for insulin secretion is glucose, and islet β-cells are particularly responsive to this important nutrient secretagogue. It is important to consider individual effects of different classes of nutrient or other physiological or pharmacological agents on metabolism and insulin secretion. However, given that β-cells are continually exposed to a complex milieu of nutrients and other circulating factors, it is important to also acknowledge and examine the interplay between glucose metabolism and that of the two other primary nutrient classes, the amino acids and fatty acids. It is the mixed nutrient sensing and outputs of glucose, amino and fatty acid metabolism that generate the metabolic coupling factors (MCFs) involved in signaling for insulin exocytosis. Primary MCFs in the β-cell include ATP, NADPH, glutamate, long chain acyl-CoA and diacylglycerol and are discussed in detail in this article. |
| first_indexed | 2025-11-14T07:48:26Z |
| format | Book Chapter |
| id | curtin-20.500.11937-23498 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:48:26Z |
| publishDate | 2015 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-234982017-09-13T13:59:02Z (Dys)Regulation of Insulin Secretion by Macronutrients Newsholme, Philip Keane, Kevin Gaudel, C. McClenaghan, N. Md. Shahidul Islam Gene expression Pancreatic ß-cells Stimulus-secretion coupling Incretins Insulin secretion Desensitization Nutrient metabolism Signal transduction Pancreatic β-cells are often referred to as “fuel sensors” as they continually monitor and respond to dietary nutrients, under the modulation of additional neurohormonal signals, in order to secrete insulin to best meet the needs of the organism. β-Cell nutrient sensing requires metabolic activation, resulting in production of stimulus-secretion coupling signals that promote insulin biosynthesis and release. The primary stimulus for insulin secretion is glucose, and islet β-cells are particularly responsive to this important nutrient secretagogue. It is important to consider individual effects of different classes of nutrient or other physiological or pharmacological agents on metabolism and insulin secretion. However, given that β-cells are continually exposed to a complex milieu of nutrients and other circulating factors, it is important to also acknowledge and examine the interplay between glucose metabolism and that of the two other primary nutrient classes, the amino acids and fatty acids. It is the mixed nutrient sensing and outputs of glucose, amino and fatty acid metabolism that generate the metabolic coupling factors (MCFs) involved in signaling for insulin exocytosis. Primary MCFs in the β-cell include ATP, NADPH, glutamate, long chain acyl-CoA and diacylglycerol and are discussed in detail in this article. 2015 Book Chapter http://hdl.handle.net/20.500.11937/23498 10.1007/978-94-007-6686-0_4 Springer restricted |
| spellingShingle | Gene expression Pancreatic ß-cells Stimulus-secretion coupling Incretins Insulin secretion Desensitization Nutrient metabolism Signal transduction Newsholme, Philip Keane, Kevin Gaudel, C. McClenaghan, N. (Dys)Regulation of Insulin Secretion by Macronutrients |
| title | (Dys)Regulation of Insulin Secretion by Macronutrients |
| title_full | (Dys)Regulation of Insulin Secretion by Macronutrients |
| title_fullStr | (Dys)Regulation of Insulin Secretion by Macronutrients |
| title_full_unstemmed | (Dys)Regulation of Insulin Secretion by Macronutrients |
| title_short | (Dys)Regulation of Insulin Secretion by Macronutrients |
| title_sort | (dys)regulation of insulin secretion by macronutrients |
| topic | Gene expression Pancreatic ß-cells Stimulus-secretion coupling Incretins Insulin secretion Desensitization Nutrient metabolism Signal transduction |
| url | http://hdl.handle.net/20.500.11937/23498 |