Longitudinal hand function in Rett syndrome
Loss of hand function is a core feature of Rett syndrome. This article describes longitudinal hand function at 3 time points for 72 subjects participating in the Australian Rett Syndrome Database. Approximately 40% of subjects with some grasping abilities lost skill over the 3- to 4-year period betw...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
Sage Publications, Inc.
2011
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/23479 |
| _version_ | 1848751163057373184 |
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| author | Downs, Jennepher Bebbington, A. Kaufmann, W. Leonard, H. |
| author_facet | Downs, Jennepher Bebbington, A. Kaufmann, W. Leonard, H. |
| author_sort | Downs, Jennepher |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Loss of hand function is a core feature of Rett syndrome. This article describes longitudinal hand function at 3 time points for 72 subjects participating in the Australian Rett Syndrome Database. Approximately 40% of subjects with some grasping abilities lost skill over the 3- to 4-year period between video assessments. In these subjects, a decrease in hand function was seen less frequently in girls 13 to 19 years old than in those younger than 8 years, in subjects with some mobility compared with those who were wheelchair bound, and in those who had previously been able to finger feed. Relationships with the magnitude of change reflected these findings. Change in hand function did not vary with clinical severity. The results for all subjects were similar to results obtained when analysis was restricted to those with a pathogenic mutation. Variability in the longitudinal course of hand function in Rett syndrome was observed. |
| first_indexed | 2025-11-14T07:48:21Z |
| format | Journal Article |
| id | curtin-20.500.11937-23479 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:48:21Z |
| publishDate | 2011 |
| publisher | Sage Publications, Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-234792017-09-13T13:57:43Z Longitudinal hand function in Rett syndrome Downs, Jennepher Bebbington, A. Kaufmann, W. Leonard, H. Rett syndrome hand function MECP2 phenotype longitudinal Loss of hand function is a core feature of Rett syndrome. This article describes longitudinal hand function at 3 time points for 72 subjects participating in the Australian Rett Syndrome Database. Approximately 40% of subjects with some grasping abilities lost skill over the 3- to 4-year period between video assessments. In these subjects, a decrease in hand function was seen less frequently in girls 13 to 19 years old than in those younger than 8 years, in subjects with some mobility compared with those who were wheelchair bound, and in those who had previously been able to finger feed. Relationships with the magnitude of change reflected these findings. Change in hand function did not vary with clinical severity. The results for all subjects were similar to results obtained when analysis was restricted to those with a pathogenic mutation. Variability in the longitudinal course of hand function in Rett syndrome was observed. 2011 Journal Article http://hdl.handle.net/20.500.11937/23479 10.1177/0883073810381920 Sage Publications, Inc. restricted |
| spellingShingle | Rett syndrome hand function MECP2 phenotype longitudinal Downs, Jennepher Bebbington, A. Kaufmann, W. Leonard, H. Longitudinal hand function in Rett syndrome |
| title | Longitudinal hand function in Rett syndrome |
| title_full | Longitudinal hand function in Rett syndrome |
| title_fullStr | Longitudinal hand function in Rett syndrome |
| title_full_unstemmed | Longitudinal hand function in Rett syndrome |
| title_short | Longitudinal hand function in Rett syndrome |
| title_sort | longitudinal hand function in rett syndrome |
| topic | Rett syndrome hand function MECP2 phenotype longitudinal |
| url | http://hdl.handle.net/20.500.11937/23479 |