Studies on carbohydrate xenoantigens
Naturally occurring and elicited anti-carbohydrate antibodies play a major role in immune responses to xenografts. The original obstacles associated with the Gal antigen have been largely resolved by the generation of knockout pigs. In contrast, much less is known about the nature and role of non-Ga...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Published: |
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/23356 |
| _version_ | 1848751127841996800 |
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| author | Christiansen, D. Mouhtouris, E. Ramsland, Paul Sandrin, M. |
| author_facet | Christiansen, D. Mouhtouris, E. Ramsland, Paul Sandrin, M. |
| author_sort | Christiansen, D. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Naturally occurring and elicited anti-carbohydrate antibodies play a major role in immune responses to xenografts. The original obstacles associated with the Gal antigen have been largely resolved by the generation of knockout pigs. In contrast, much less is known about the nature and role of non-Gal carbohydrate antigens and the antibodies recognizing these. These antibodies can be identified and characterized by enzyme-linked immunosorbent assay. Furthermore, the biological significance of the non-Gal antigen(s) can be determined by expression of the relevant glycosyltransferase(s) by transfection and analyzed by antibody and/or lectin binding. © 2012 Springer Science+Business Media, LLC. |
| first_indexed | 2025-11-14T07:47:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-23356 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:47:47Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-233562017-09-13T13:58:22Z Studies on carbohydrate xenoantigens Christiansen, D. Mouhtouris, E. Ramsland, Paul Sandrin, M. Naturally occurring and elicited anti-carbohydrate antibodies play a major role in immune responses to xenografts. The original obstacles associated with the Gal antigen have been largely resolved by the generation of knockout pigs. In contrast, much less is known about the nature and role of non-Gal carbohydrate antigens and the antibodies recognizing these. These antibodies can be identified and characterized by enzyme-linked immunosorbent assay. Furthermore, the biological significance of the non-Gal antigen(s) can be determined by expression of the relevant glycosyltransferase(s) by transfection and analyzed by antibody and/or lectin binding. © 2012 Springer Science+Business Media, LLC. 2012 Journal Article http://hdl.handle.net/20.500.11937/23356 10.1007/978-1-61779-845-0_4 restricted |
| spellingShingle | Christiansen, D. Mouhtouris, E. Ramsland, Paul Sandrin, M. Studies on carbohydrate xenoantigens |
| title | Studies on carbohydrate xenoantigens |
| title_full | Studies on carbohydrate xenoantigens |
| title_fullStr | Studies on carbohydrate xenoantigens |
| title_full_unstemmed | Studies on carbohydrate xenoantigens |
| title_short | Studies on carbohydrate xenoantigens |
| title_sort | studies on carbohydrate xenoantigens |
| url | http://hdl.handle.net/20.500.11937/23356 |