An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations
In previous studies, we have shown that a gliclazide-cholic acid derivative (G-CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about a significant hypoglycaemic effect. In this study, we aim to create a novel microencapsulate...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
TAYLOR & FRANCIS LTD
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/23183 |
| _version_ | 1848751079372619776 |
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| author | Mooranian, A. Negrulj, R. Mathavan, S. Martinez, J. Sciarretta, J. Chen-Tan, N. Mukkur, T. Mikov, M. Lalic-Popovic, M. Stojancevic, M. Golocorbin-Kon, S. Al-Salami, Hani |
| author_facet | Mooranian, A. Negrulj, R. Mathavan, S. Martinez, J. Sciarretta, J. Chen-Tan, N. Mukkur, T. Mikov, M. Lalic-Popovic, M. Stojancevic, M. Golocorbin-Kon, S. Al-Salami, Hani |
| author_sort | Mooranian, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In previous studies, we have shown that a gliclazide-cholic acid derivative (G-CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about a significant hypoglycaemic effect. In this study, we aim to create a novel microencapsulated-formulation of G-CA with uniform and coherent structure that can be further tested in our rat model of type 1 diabetes (T1D). We also aim to examine the effect of CA addition to G microcapsules in the morphology, structure and excipients' compatibility of the newly designed microcapsules. |
| first_indexed | 2025-11-14T07:47:01Z |
| format | Journal Article |
| id | curtin-20.500.11937-23183 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:47:01Z |
| publishDate | 2015 |
| publisher | TAYLOR & FRANCIS LTD |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-231832017-09-13T13:56:21Z An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations Mooranian, A. Negrulj, R. Mathavan, S. Martinez, J. Sciarretta, J. Chen-Tan, N. Mukkur, T. Mikov, M. Lalic-Popovic, M. Stojancevic, M. Golocorbin-Kon, S. Al-Salami, Hani In previous studies, we have shown that a gliclazide-cholic acid derivative (G-CA) mixture resulted in an enhanced ileal permeation of G (ex vivo). When administered orally to diabetic rats, it brought about a significant hypoglycaemic effect. In this study, we aim to create a novel microencapsulated-formulation of G-CA with uniform and coherent structure that can be further tested in our rat model of type 1 diabetes (T1D). We also aim to examine the effect of CA addition to G microcapsules in the morphology, structure and excipients' compatibility of the newly designed microcapsules. 2015 Journal Article http://hdl.handle.net/20.500.11937/23183 10.3109/10837450.2014.915570 TAYLOR & FRANCIS LTD restricted |
| spellingShingle | Mooranian, A. Negrulj, R. Mathavan, S. Martinez, J. Sciarretta, J. Chen-Tan, N. Mukkur, T. Mikov, M. Lalic-Popovic, M. Stojancevic, M. Golocorbin-Kon, S. Al-Salami, Hani An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations |
| title | An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations |
| title_full | An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations |
| title_fullStr | An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations |
| title_full_unstemmed | An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations |
| title_short | An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations |
| title_sort | advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations |
| url | http://hdl.handle.net/20.500.11937/23183 |